复方甘草酸苷与干扰素α-2b联合治疗慢性乙型肝炎的临床观察

目的 评价复方甘草酸苷与干扰α-2b联合治疗慢性乙型肝炎的临床疗效.方法 将76例慢性乙型肝炎患者完全随机分为治疗组（39例）和对照组（37例）.治疗组由复方甘草酸苷和干扰素α-2b联合治疗;对照组为单用干扰素α-2b.对比2组患者临床各指标恢复情况.结果 与对照组比较,治疗组在治疗结束时的HBsAg转阴率、HBeAg转阴率、HBeAb转阳率和HBV-DNA转阴率各指标均明显高于对照组7.7%比2.7%,64.1%比40.5%,53.8%比29.7%,71.8%比48.6%,P＜0.05或P＜0.01];随访6个月后,ALT复常率、HBeAg转阴率、HBeAb转阳率和HBV-DNA转阴率均明显高于对照组（P＜0.05或P＜0.01）.结论 复方甘草酸苷与干扰素α-2b联合治疗慢性乙型肝炎的临床疗效明显优于单用干扰素α-2b.

Clinical observation of the effect of compound glycyrrhizin and interferon α-2b in treating chronic hepatitis B

Objective To investigate the clinical effect of compound glycyrrhizin combined with interferon α-2b on chronic hepatitis B (CHB). Methods Seventy-six CHB patients were randomly assigned into treatment group (39 cases) and control group (37 cases). Treatment group were given compound glycyrrhizin (100 ml, 80 ml and 60 ml for 4 weeks respectively) combined with interferonα-2b (once a day for 4 weeks, and then 500 MU interferon a every day for 32 weeks) and control group were given the same dose of interferonα-2b. All patients were treated for 36 weeks and then were followed up for 24 weeks. Results By the end of therapeutic course, the rates of negative conversion of HBsAg, HBeAg, HBV-DNA and the rates of positive conversion of HbeAb in the experimental group were much higher those in control. By the end of follow-up, the ALT recovery rates, the rates of negative conversion of HBeAg and HBV-DNA and the rates of positive conversion of HbeAb in the experimental group have statistically higher than those in control. Conclusion The efficacy of compound glycyrrhizin combined with interferon α-2b treatment for CHB patients is high.