血栓通注射液治疗额颞叶脑挫裂伤伴血肿的临床观察

目的 观察血栓通注射液治疗额颞叶脑挫裂伤伴血肿的临床效果.方法 将轻中度额颞叶脑挫裂伤伴血肿形成的94例患者按随机数字表分为观察组及对照组,每组47例.对照组采用常规治疗;观察组在常规治疗基础上加用血栓通注射液0.5g静脉滴注,1次/d,连用14 d.治疗14 d后,评定临床疗效、神经功能及生活质量（Barthel指数）.结果 治疗14 d后,观察组总有效率明显高于对照组78.7％（37/47）比59.6％ （28/47）],差异有统计学意义（P＜0.05）;观察组和对照组神经功能缺损积分均低于治疗前（13±6）分比（25±6）分,（16±6）分比（24±5）分,均P＜0.05],且观察组明显低于对照组（P＜0.05）;观察组和对照组治疗14 d后Barthel评分均较治疗前改善（73±18）分比（34±18）分,（61±17）分比（36±18）分],差异有统计学意义（P＜0.05）,但观察组明显高于对照组（P＜0.05）;治疗14 d后,观察组和对照组血肿较治疗前明显缩小（1.4±0.9）ml比（18.1±9.2）ml,（2.9±1.4）ml比（16.9±9.8）ml],差异有统计学意义（P＜0.05）,但观察组血肿体积明显少于对照组（P＜0.05）.结论 血栓通注射液治疗脑挫裂伤伴血肿较内科常规方法有更好的临床疗效,能明显促进血肿吸收,促进神经功能恢复,改善日常生活活动能力,提高临床疗效.

Treatment of frontotemporal lobe cerebral contusion with Xueshuantong injection

Objective To observe the clinical efficacy of Xueshuantong injection in the treatment of frontotemporal lobe cerebral contusion.Methods All 94 patients were randomly divided into control group and observation group; the control group was treated with conventional therapy and the observation group was added the Xueshuantong injection; the observation time was three weeks.The clinical efficacy,neurological deficit and the activities of daily living were assessed.Results After treatment of 14 days,the total effective rate in observation group was higher than that in control group 78.7% （37/47） vs 59.6% （28/47）,P 〈 0.05] ; the scores of neurological deficit in observation group and control group were less than those before treatment （13 ±6）scores vs （25 ± 6） scores,（16 ± 6） scores vs （24 ± 5） scores,all P 〈 0.05],and the scores of observation group were lower than those of control group （P 〈 0.05） ; the scores of Bathel scores in observation group and control group were higher than those before treatment （73 ± 18）scores vs （34 ± 18）scores,（61 ± 17）scores vs （36 ± 18）scores,all P 〈0.05],and the scores of observation group were more than those of control group （P 〈 0.05） ; the volume of hematoma in observation group and control group was less than that before treatment （1.4 ± 0.9） ml vs （18.1 ±9.2） ml,（2.9 ± 1.4） ml vs （16.9 ± 9.8） ml],and the volume of observation group was less than that of control group （P 〈 0.05）.Conclusion Xueshuantong injection in the treatment of cerebral contusion can significantly promote the absorption of hematoma and the recovery of neurological function.