不同促排卵法治疗多囊卵巢综合征伴不孕症患者的临床观察

目的评估3种促排卵方法治疗多囊卵巢综合征（PCOS）合并不孕症的临床效果。方法将75例PCOS不孕症患者采用完全随机设计方法分为3组各25例，氯米芬（CC）组给予CC治疗；尿促性素（HMG）组给予HMG方案，CC＋HMG组给予CC＋HMG序贯治疗。观察3组排卵率、妊娠率及并发症情况。结果CC组、HMG组和CC＋HMG组排卵率分别为61．5％，87．7％，88．1％；妊娠率分别为24％，60％，56％：HMG组和CC＋HMG组与CC组相比排卵率及妊娠率均升高，差异有统计学意义（P〈0．05）。HMG组与CC＋HMG组排卵率、妊娠率比较无统计学意义（P〉0．05）；但多胎妊娠率及卵巢过度刺激综合征（OHSS）发生率比较，HMG组高于CC组和CC＋HMG组（P〈0．05）。结论采用HMG及CC＋HMG序贯方案优于CC的促排卵治疗，CC＋HMG方案保证妊娠率的同时可以降低多胎妊娠及OHSS的发生。

Clinical analysis of different ovulation induction therapies for patients with polycystic ovarian syndrome related infertility

Objective To investigate the effects of three kinds of ovulation induction therapies for patients with Polycystic Ovarian Syndrome (PCOS)related infertility. Methods Seventy-five patients of PCOS related infertility were divided into three groups (group1, 2, 3) randomly. Patients in different groups were treated with Clomide(CC), human menopasual gonadotropin (HMG)and CC + HMG in sequential respectively. The ovulation rates,pregnancy rates and complications were analyzed. Results The ovulation rates were 61.5% ,87.7% and 88. 1% in group 1,2,3. The pregnancy rates were 24% ,60% and 56% in group 1,2,3, with significant difference between group 1 and group 2 or 3 (P < 0.05). There was no difference between group 2 and 3 in ovulation rates or pregnancy rates (P > 0. 05). There was difference of occurrence rates of Ovarian Hyperstimulation Syndrome (OHSS) and twins between group 2 and group 1 or 3 (P < 0.05). Conclusion HMG and CC + HMG are better than CC ovulation induction therapies and CC might decrease the occurrence rates of OHSS and multiple pregnancy.