氨曲南的合成 |
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引用本文: | 邓启华,张宏,黄文才.氨曲南的合成[J].中国医药工业杂志,2009,40(10). |
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作者姓名: | 邓启华 张宏 黄文才 |
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作者单位: | 邓启华,张宏(四川大学化工学院,四川成都,610065;四川化工职业技术学院,四川泸州,646005);黄文才(四川大学化工学院,四川成都,610065) |
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摘 要: | trans-3(S)-氨基-4-甲基-2-氧代-1-氮杂环丁烷基磺酸和头孢他啶侧链活性酯经酰胺化、脱叔丁酯基得到a-型氨曲南.溶十无水乙醇后经脱色、过滤,加入少量β-型氨曲南的晶种,于5~10℃剧烈搅拌7 h后过滤,得到纯度99.5%的β-型氨曲南,溶剂乙醇残留量为0.3%.
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关 键 词: | 氨曲南 抗生素 纯化 晶型转化 合成 |
Synthesis of Aztreonam |
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Abstract: | trans-3(S)-Amino-4-methyl-2-oxoazetidine-1-sulfonic acid was amided with the activated thioester of ceftazidime side chain and deprotection to afford α-form aztreonam,which after dissolution in ethanol,decolorization and fi ltration,seeded with β-form aztreonam and stirred for 7h at 5-10 ℃ to give β-form aztreonam with 99.5% purity and 0.3% residual ethanol. |
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Keywords: | aztreonam antibiotic purification crystalline form transformation synthesis |
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