| 地尔硫(艹卓)口服生物粘附缓释胶囊的制备 |
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| 引用本文： | 付劼,蒋煜,孙逊,张志荣.地尔硫(艹卓)口服生物粘附缓释胶囊的制备[J].中国医药工业杂志,2003,34(9). |
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| 作者姓名： | 付劼 蒋煜 孙逊 张志荣 |
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| 作者单位： | 四川大学华西药学院,四川成都,610041 |
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| 基金项目： | 国家杰出青年科学基金项目 (3 992 5 0 3 9) |
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| 摘 要： | 应用多元线性回归方法考察卡波姆 934、丙烯酸树脂 II、硬脂酸对盐酸地尔硫释放的影响 ,通过调整各辅料的用量比例 ,制备在不同溶出介质中具有相同释药曲线且能维持 2 4 h释药的地尔硫粘附胶囊。根据各个释放模型拟合的 AIC值、计算值与实测值的相对误差来研究其释药规律。根据 Peppas方程特征参数判断其释药机制主要为药物扩散。
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| 关 键 词： | 盐酸地尔硫 口服生物粘附制剂 卡波姆934 缓释胶囊 多元线性回归 |
Preparation of Oral Bioadhesive Sustained Release Capsules of Diltiazem |
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| Abstract: | A multiple linear regression equation was applied to investigate effects of Carbomer 934, Eudragit II and stearic acid on release rate of diltiazem hydrochloride. The 24 h sustained release capsules of diltiazem hydrochloride had the same release rate curve in three different mediums by adjusting the proportion of excipients. According to the value of AIC and relative errors between calculated and measured values, the release rule was determined. The values of characteristic parameter of Peppas equation indicated that release mechanism of diltiazem was diffusion release. |
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| Keywords: | diltiazem hydrochloride oral bioadhesive preparation Carbomer 934 sustained release capsules multiple linear regression |
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