| 体外黏附力的测定及在生物黏附制剂处方筛选的试用 |
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| 引用本文： | 高朝霞,蒋学华,张川川,李晨睿.体外黏附力的测定及在生物黏附制剂处方筛选的试用[J].中国医药工业杂志,2006,37(9):606-609. |
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| 作者姓名： | 高朝霞 蒋学华 张川川 李晨睿 |
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| 作者单位： | 1. 成都军区总医院药剂科,四川,成都,610083;四川大学华西药学院,四川,成都,610041
2. 四川大学华西药学院,四川,成都,610041 |
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| 摘 要： | 采用自制的体外黏附力测定装置，以同一大鼠的离体小肠测定生物黏附缓释片的黏附性能。并以黏附力、体外释放度两个指标筛选优化处方。结果表明，自制装置结构简单，所建立的方法可用于生物黏附制剂的处方筛选。
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| 关 键 词： | 生物黏附制剂 黏附力 处方筛选 |
| 文章编号： | 1001-8255（2006）09-0606-04 |
| 收稿时间： | 2005-07-11 |
| 修稿时间： | 2005-07-11 |
Determination of in vitro Adhesive Force and Its Application in Formulation of Bioadhesive Tablets |
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| Authors: | GAO Zhao-Xia JIANG Xue-Hua ZHANG Chuan-Chuan LI Chen-Rui |
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| Institution: | 1. Dept. of Pharmacy, General Hospital of Chengdu Military Command of PLA, Chengdu 610083;2. West China School of Pharmacy, Sichuan University, Chengdu 610041 |
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| Abstract: | The adhesive ability of the prepared bioadhesive tablets was measured using excised small intestine of same rat by domestic adhesive force determination device. The formulation was optimized using adhesive force and in vitro release as two evaluation parameters. The results showed that domestic device was simple and the method could be used to screen the formulation of bioadhesive preparations. |
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| Keywords: | bioadhesive preparation adhesive force formulation screening |
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