65例脑血管硬化性痴呆症患者ET、CGRP、NO的变化

目的：观察脑血管硬化性痴呆症（VD）患者血清ET、CGRP与NO的水平，分析其相互关系，探讨血管舒缩功能状态改变与VD发病的可能关系。方法：根据诊断标准筛选VD患者65例，分为轻度痴呆组（VD.1)30例，重度痴呆组（VD.2)35例，并设立正常对照组30例，进行血清ET、CGRP、NO指标检测。结果：VD组ET显著高于正常对照组，CGRP、NO显著低于正常对照组（P＜0.01)；VD.2组ET高于VD.1组，CGRP、NO低于VD.1组（P＜0.01)；VD患者的ET与CGRP、NO呈负相关性，CGRP与NO与正相关（P＜0.01)。结论：在VD患者血中ET升高，CGRP、NO降低，VD的发病与血管舒缩调节功能异常有关。

Changes of Serum Levels of ET, CGRP, NO in Patients with Vascular Dementia

Objective:To study involvement of vasomotory function in the mechanism of vascular dementia(VD)by assessing levels of serum ET,CGRP,NO and analyzing their correlation Methods:65 cases of VD were divided into group VD1(mild dementia,n=30) and VD2(severe dementia,n=35),and compared their serum ET,CGRP,NO with those in normal control(n=30) It was found that serum ET in VD were significantly higher than those in normal control(P<0 01),but CGRP,NO in the former were significantly lower than those in the latter(P<0 01),and serum ET in VD2 were higher than those in VD1,but CGRP,NO in VD2 were lower than those in VD1(P<0 01) Serum ET in VD was either negatively correlated with CGRP or NO,and serum CGRP was positively correlated with NO(p<0 01) Conclusion:Serum ET in VD patients increase and serum CGRP,NO in VD decrease Mechanism of development of VD involves abnormality of vasomotory function