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| 乌苏里藜芦碱抗血栓作用机制的研究 | |
| 引用本文： | 杨静娴,史相国,徐志立,闫宇辉,吕莉,韩国柱.乌苏里藜芦碱抗血栓作用机制的研究[J].中国医药指南,2010,8(32):177-178. |
| 作者姓名： | 杨静娴 史相国 徐志立 闫宇辉 吕莉 韩国柱 |
| 作者单位： | 1. 辽宁中医药大学药学院,116601 2. 大连市第七人民医院,116023 3. 大连医科大学药学院,116044 |
| 基金项目： | 辽宁省教育厅科研项目 |
| 摘 要： | 目的研究乌苏里藜芦碱(VnA)抗血栓作用的机制。方法建立血瘀大鼠模型,检测VnA治疗前后血小板聚集率及血浆TXA2和PGI2水平的变化。结果静脉注射VnA可显著降低血小板聚集率,使血浆TXA2水平降低,PGI2水平升高。结论 VnA可显著抑制血小板聚集,其机制可能与升高血浆PGI2与TXA2比值有关。 |
| 关 键 词： | 乌苏里藜芦碱 抗血栓作用 血小板 前列腺素I2 血栓素A2 |
Study on Mechnism of Antithrombotic Effect of Veratrum Nigrutn L.var.Utsurience Nakai Alkaloids |
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| YANG Jing-xian,SHI Xiang-guo,XU Zhi-li,YAN Yu-hui,LV Li,HAN Guo-zhu.Study on Mechnism of Antithrombotic Effect of Veratrum Nigrutn L.var.Utsurience Nakai Alkaloids[J].Guide of China Medicine,2010,8(32):177-178. | |
| Authors: | YANG Jing-xian SHI Xiang-guo XU Zhi-li YAN Yu-hui LV Li HAN Guo-zhu |
| Institution: | 1. School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116601, China; 2. Dalian 7th Hospital, Dalian, 116023, China; 3.School of Pharmacy, Dalian Medical University, Dalian 116044, China) |
| Abstract: | Objective To study the mechanism of antithrombotic effect of Veratrum nigrum L. var. ussurience Nakai alkaloids （VnA）. Methods Blood stasis models were made and treated with VnA intravenously. The blood samples were collected and tested for platelet aggregation, concentrations of plasma TXA2 and PGI2. Results In comparison with control blood stasis model, V nA treatment significantly inhibited platelet aggregation, decreased plasma TXA2, and increased plasma PGI2. Conclusion VnA increased the ratio of PGI2 and TXA2, thereby inhibiting platelet aggregation. |
| Keywords: | Veratrum nigrum L var ussurience Nakai alkaloids Antithrombotic effect Platelet PGI2 TXA2 |
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