卡维地洛联合常规抗心衰药物治疗慢性心力衰竭49例临床观察

观察卡维地洛联合常规治疗方法在治疗慢性心力衰竭（CHF）中的疗效。选取我院49例慢性心力衰竭患者，随机分为常规方法治疗组21例，卡维地洛联合常规方法治疗组28例。其中，常规治疗方法包括正性肌力药，血管紧张素转换酶抑制剂（ACEI），利尿剂。联合治疗组为常规治疗方法加用卡维地洛。每隔2周随访一次，共随访7个月，用超声心动图分别测量评价治疗前后的心功能。联合治疗组和常规治疗组相比于治疗前，LVEDD、LVESD均较治疗前显著减小，LVEF较治疗前显著提高（P〈0．01），相比于常规治疗组，联合治疗组治疗效果更好，差异有统计学意义（P〈0．01）。

Clinical Observation of 49 Cases on Treatment of CHF by Carvedilol Combined with Routine Medicine of CHF

Objective To observe the therapy effect of carvedilol combined with conventional therapy in the treatment of chronic heart failure （CHF）. Methods The selected 49 patients with chronic heart failure in our hospital were randomly divided into conventional therapy group, n=21 and combined therapy group, n=28. Among them, the conventional treatment methods includes positive inotropic drugs, angiotensin converting enzyme inhibitors （ACEI） and diuretics. The combined therapy group used carvedilol on the base of conventional therapy. Follow-up once every two weeks, a total follow-up for 7 month. Echocardiography was used to mesure and evaluate the heart function before and after treatment. Conclusions LVEDD and LVESD significantly decreased and LVEF significantly increased compared with those before treatment in both conventional therapy group and combined therapy group （P〈0.01）. The combined therapy group＇s treatment effect is better than the conventional therapy group＇s. The difference was statistically significant （P〈0.01） .