| 滋肾降糖丸对高脂小鼠模型胰岛素敏感性的影响及其机制 |
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| 引用本文： | 肖永平,郭彬,凌英蓉.滋肾降糖丸对高脂小鼠模型胰岛素敏感性的影响及其机制[J].中国医药指南,2012,10(13):7-9. |
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| 作者姓名： | 肖永平 郭彬 凌英蓉 |
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| 作者单位： | 广东省深圳市中医院药剂科,广东,深圳,518033 |
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| 摘 要： | 目的探讨滋肾降糖丸对胰岛素敏感性的影响及其分子机制。方法建立高脂饲喂的胰岛素抵抗小鼠模型,血生化检测滋肾降糖丸对该模型胰岛素敏感指数的影响,q-PCR检测滋肾降糖丸对该模型肌肉Glut4基因表达的影响。结果滋肾降糖丸显著促进高脂抵抗小鼠模型胰岛素敏感指数,同时显著上调肌肉Glut4 mRNA的表达。结论滋肾降糖丸具有改善胰岛素敏感性的作用,其机制可能与上调肌肉组织中Glut4基因表达有关。
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| 关 键 词： | 滋肾降糖丸 胰岛素敏感性 高脂食物 |
Effect of Zi-Shen-Jian-Tang Pills on Insulin Sensitivity of High-fat Diet-fed Mouse and Action Mechanisms |
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| XIAO Yong-ping
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GUO Bin
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LING Ying-rong.Effect of Zi-Shen-Jian-Tang Pills on Insulin Sensitivity of High-fat Diet-fed Mouse and Action Mechanisms[J].Guide of China Medicine,2012,10(13):7-9. |
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| Authors: | XIAO Yong-ping GUO Bin LING Ying-rong |
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| Institution: | (Department of Pharmacy,Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518033,China) |
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| Abstract: | Objective To investigate the effect of Zi-Shen-Jian-Tang pills on insulin sensitivity of high-fat diet-fed mouse and action mechanisms.Methods Index of insulin sensitivity was assayed by using biochemical methods and Glut4 mRNA expression in muscles of high-fat diet-fed mice was measured by q-PCR.Results Zi-Shen-Jian-Tang pills significantly increase the index of insulin sensitivity and upregulate the expression of Glut4 in muscles of high-fat diet-fed mice.Conclusions Zi-Shen-Jian-Tang pills may increase the insulin sensitivity mediated by up-regulating the expression of Glut4 mRNA in muscles. |
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| Keywords: | Zi-Shen-Jian-Tang pills Insulin sensitivity Fatty foods |
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