| 异戊烯基口占吨酮类天然产物的抗肿瘤活性研究进展 |
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| 引用本文： | 王帆,叶红春,夏开国,尤启冬,徐嘉莹,王泳鑫,王进欣.异戊烯基口占吨酮类天然产物的抗肿瘤活性研究进展[J].药学进展,2011,35(7):304-311. |
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| 作者姓名： | 王帆 叶红春 夏开国 尤启冬 徐嘉莹 王泳鑫 王进欣 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏,南京,210009 |
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| 基金项目： | 国家自然科学基金，江苏省2008年度"青蓝工程"优秀骨干教师培养项目 |
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| 摘 要： | 近年来有研究显示，含有异戊烯基结构的天然咕吨酮类化合物对多种肿瘤具有显著抑制活性，故而从此类化合物中寻找具有开发价值的抗肿瘤先导化合物，已成为一个研究热点。按来源分别介绍异戊烯基咕吨酮类天然化合物及其抗肿瘤活性研究新进展，并对其中部分化合物的作用机制及构效关系进行了初步探讨。
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| 关 键 词： | 咕吨酮 异戊烯基 抗肿瘤活性 |
Advances in Research On Anti-tumor Activity of Natural Prenylated Xanthones |
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| WANG Fan,YE Hong-chun,XIA Kai-gu,YOU Qi-dong,XU Jia-ying,WANG Yong-xin,WANG Jin-xin.Advances in Research On Anti-tumor Activity of Natural Prenylated Xanthones[J].Progress in Pharmaceutical Sciences,2011,35(7):304-311. |
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| Authors: | WANG Fan YE Hong-chun XIA Kai-gu YOU Qi-dong XU Jia-ying WANG Yong-xin WANG Jin-xin |
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| Institution: | WANG Fan,YE Hong-chun,XIA Kai-guo,YOU Qi-dong,XU Jia-ying,WANG Yong-xin,WANG Jin-xin(Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Recently,some reports have shown that the prenylated xanthones from the natural products have significant inhibitory activity against several kinds of tumors,so it has become a meaningful and potential research direction for people to discover the lead compounds from the natural prenylated xanthones which possess anti-tumor activity.The recent progress in research on the prenylated xanthones isolated from the natural products and their anti-tumor activity were introduced in this article.Moreover,the mechani... |
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| Keywords: | xanthone prenyl anti-tumor activity |
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