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| 来源于天然产物的乙酰胆碱酯酶抑制剂研究进展 | |
| 引用本文： | 楼影涵,查晓明,张莉莉,张茵,徐云根,张陆勇.来源于天然产物的乙酰胆碱酯酶抑制剂研究进展[J].药学进展,2012,36(9):385-393. |
| 作者姓名： | 楼影涵 查晓明 张莉莉 张茵 徐云根 张陆勇 |
| 作者单位： | 1. 中国药科大学新药筛选中心,江苏南京210009;中国药科大学药物化学教研室,江苏南京210009 2. 中国药科大学新药筛选中心,江苏南京,210009 3. 中国药科大学新药筛选中心,江苏南京210009;中国药科大学天然药物化学教研室,江苏南京210009 4. 中国药科大学药物化学教研室,江苏南京,210009 |
| 基金项目： | 江苏省自然科学基金(No.BK2011622) |
| 摘 要： | 乙酰胆碱酯酶抑制剂可用于治疗阿尔茨海默病、运动失调、重症肌无力等多种神经系统疾病,按来源可分为化学合成和天然产物两大类,而天然产物是其重要来源.综述来源于植物、微生物及动物并具不同结构类型的乙酰胆碱酯酶抑制剂的研究进展. |
| 关 键 词： | 乙酰胆碱酯酶抑制剂 天然产物 抑制活性 |
Advances in Acetylcholesterase Inhibitors Derived from Natural Products |
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| LOU Ying-han , ZHA Xiao-ming , ZHANG Li-li , ZHANG Yin , XU Yun-gen , ZHANG Lu-yong.Advances in Acetylcholesterase Inhibitors Derived from Natural Products[J].Progress in Pharmaceutical Sciences,2012,36(9):385-393. | |
| Authors: | LOU Ying-han ZHA Xiao-ming ZHANG Li-li ZHANG Yin XU Yun-gen ZHANG Lu-yong |
| Institution: | 1(1.Center for Drug Screening,China Pharmaceutical University,Nanjing 210009,China;2.Department of Medical Chemistry,China Pharmaceutical University,Nanjing 210009,China;3.Department of Phytoche-mistry,China Pharmaceutical University,Nanjing 210009,China) |
| Abstract: | Acetylcholinesterase inhibitors(AChEIs) are considered as a promising strategy for the treatment of neurological disorders,such as Alzheimer′s disease,ataxia and myasthenia gravis.AChEIs could be usually classified as the synthetic and the natural products according to the different origins.The advances in AChEIs with different structures derived from plants,micro-organisms and animals were reviewed. |
| Keywords: | acetylcholinesterase inhibitor natural product inhibitory activity |
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