| 白桦酸及其衍生物的研究进展 |
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| 引用本文： | 李丹,周金培,吴晓明.白桦酸及其衍生物的研究进展[J].药学进展,2004,28(3):120-125. |
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| 作者姓名： | 李丹 周金培 吴晓明 |
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| 作者单位： | 中国药科大学药学院,江苏,南京,210009 |
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| 基金项目： | 200 4年教育部科学技术研究项目 (10 4 2 2 4 ) |
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| 摘 要： | 对白桦酸衍生物的构效关系及其中的YK-FH312、RPR103611和IC9564等的作用机制及活性进行述评。天然产物白桦酸是有抗HIV和抗肿瘤活性，且具有新型结构和新型作用机制的化合物，其天然来源广泛，半合成方法成熟，是寻找抗HIV和抗肿瘤药物的优秀的先导物。通过对白桦酸的结构修饰，大量白桦酸衍生物已被合成。
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| 关 键 词： | 白桦酸 衍生物 研究进展 抗肿瘤药物 作用机制 获得性免疫缺陷综合征 |
| 文章编号： | 1001-5094(2004)03-0120-06 |
| 修稿时间： | 2003年12月23 |
Recent Advances of Betulinic Acid and Its Derivatives |
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| LI Dan,ZHOU Jin-pei,WU Xiao-ming.Recent Advances of Betulinic Acid and Its Derivatives[J].Progress in Pharmaceutical Sciences,2004,28(3):120-125. |
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| Authors: | LI Dan ZHOU Jin-pei WU Xiao-ming |
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| Abstract: | Betulinic acid, a natural product, is an anti-HIV and antitumor agent with novel structure and new mechanism of action. Not only it is found abundantly in the nature, but also its semi-synthesis approach has been successful. Betulinic acid is a perfect lead-compound. A lot of betulinic acid derivatives have been synthesized. The structure-activity relationships of Betulimic acid, The mechanisms and the effects of YK-FH312, RPR103611 and IC9564 derivated from Betulinic acid were reviewed in the paper. |
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| Keywords: | Anti-HIV Antitumor Betulinic acid Betulinic acid derivatives |
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