| 以CCR5为靶点的小分子抗艾滋病药物的研究与开发 |
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| 引用本文： | 甘海峰,查晓明,吉民.以CCR5为靶点的小分子抗艾滋病药物的研究与开发[J].药学进展,2005,29(4):151-155. |
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| 作者姓名： | 甘海峰 查晓明 吉民 |
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| 作者单位： | 1. 中国药科大学新药研究中心,南京,210009
2. 东南大学化学化工系,江苏,南京,210008 |
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| 摘 要： | 综述趋化因子受体5 (CCR5 )拮抗剂的作用机制,介绍若干具代表性的小分子CCR5拮抗剂,并探讨其构效关系。CCR5属于G蛋白偶联受体超家族,是HIV- 1入侵机体细胞的主要辅助受体之一。以CCR5为为靶点的小分子抗艾滋病药物的研究与开发备受关注。
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| 关 键 词： | 趋化因子受体5 小分子CCR5拮抗剂 作用机制 构效关系 |
| 文章编号： | 1001-5094(2005)04-0151-05 |
| 修稿时间： | 2004年10月28 |
Research and Development of CCR5-targeted Small Molecule Anti-AIDS Drugs |
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| GAN Hai-feng,ZHA Xiao-ming,JI Min.Research and Development of CCR5-targeted Small Molecule Anti-AIDS Drugs[J].Progress in Pharmaceutical Sciences,2005,29(4):151-155. |
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| Authors: | GAN Hai-feng ZHA Xiao-ming JI Min |
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| Institution: | GAN Hai-feng 1,ZHA Xiao-ming 1,JI Min 2* |
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| Abstract: | Chemokine receptor 5(CCR5), a member of the G protein-coupled receptor superfamily, is one of the major co-receptors for HIV-1 infection. Research and development of CCR5-targeted small-molecular antiAIDS drugs have aroused the interest of all. Several representative small-molecular CCR5-targeted agents have been developed in recent years. Their mechanisms of action were reviewed and their structure-activity relationship was also discussed. |
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| Keywords: | CCR5 Small molecule CCR5 antagonist Acting mechanism Structure-activity relationship |
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