| 苄达赖氨酸在10名中国青年体内的药物动力学 |
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| 引用本文： | 陈小祥,严汉英.苄达赖氨酸在10名中国青年体内的药物动力学[J].中国药理学报,1997,18(2):109-111. |
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| 作者姓名： | 陈小祥 严汉英 |
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| 作者单位： | [1]南京医科大学临床药理研究所 [2]南京药物研究所眼科药理中心 |
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| 摘 要： |
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| 关 键 词： | 苄达酸 赖氨酸 药物动力学 高压液相色谱 |
Pharmacokinetics of bendazac lysine in 10 Chinese young men. |
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| X X Chen,Y D Zhang,J P Shen,J Pu,H Y Yan,Y Q Zhu,J J Qiu.Pharmacokinetics of bendazac lysine in 10 Chinese young men.[J].Acta Pharmacologica Sinica,1997,18(2):109-111. |
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| Authors: | X X Chen Y D Zhang J P Shen J Pu H Y Yan Y Q Zhu J J Qiu |
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| Institution: | Institute of Clinical Pharmacology, Nanjing Medical University, China. |
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| Abstract: | AIM: To compare the pharmacokinetics of domestic and imported tablets of bendazao lysine (BL). METHODS: A single oral dose of 500 mg BL of this 2 kinds of tablets was given to 10 Chinese volunteers of Han nationality in a randomized crossover study. Plasma levels were determined with HPLC-UV method. Data were analyzed automatically by using a CAPP program on microcomputer. RESULTS: The plasma concentration-time curve was fitted to 2-compartment open model, and the major pharmacokinetic parameters of domestic and imported BL tablets were shown respectively as following: Cmax 66 +/- 16 and 65 +/- 8 mg.L-1; Tmax 0.98 +/- 0.22 and 0.98 +/- 0.21 h; T1/2 beta 6.2 +/- 1.8 and 6.2 +/- 1.7 h; AUC 335 +/- 47 and 337 +/- 58 mg.h.L-1. There was no significant difference between domestic and imported tablets. The bioavailability of the domestic vs that of the imported tablet was 99 +/- 12%. The unchanged BL in urine were about 5.4% and 5.6% respectively of the dosage in 24 h after a single oral dose. CONCLUSION: The two kinds of tablets had the same biological effects. |
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