| 三七皂甙升高颈动脉前列腺素I2及降低血小板血栓素A2的作用 |
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| 引用本文： | 石琳,范盘生.三七皂甙升高颈动脉前列腺素I2及降低血小板血栓素A2的作用[J].中国药理学报,1990,11(1):29-32. |
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| 作者姓名： | 石琳 范盘生 |
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| 摘 要： |
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| 关 键 词： | 动脉粥样硬化 皂甙类 血小板 三七 |
Effects of total saponins of Panax notoginseng on increasing PGI2 in carotid artery and decreasing TXA2 in blood platelets |
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| L Shi,P S Fan,L Wu,J X Fang,Z X Han.Effects of total saponins of Panax notoginseng on increasing PGI2 in carotid artery and decreasing TXA2 in blood platelets[J].Acta Pharmacologica Sinica,1990,11(1):29-32. |
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| Authors: | L Shi P S Fan L Wu J X Fang Z X Han |
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| Institution: | Department of Pharmacology, Suzhou Medical College, China. |
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| Abstract: | Total saponins of Panax notoginseng (PNS) were given orally 100 mg/(kg.d) to rabbit for 8 wk. Aortic atherosclerotic plaque formation was restrained as compared to the control group. Radioimmunoassay was used to investigate the effects of PNS on the contents of prostacyclin in carotid artery and thromboxane A2 in blood platelets of rat. Oral administration of PNS 25,50,100 mg/(kg.d) for 10 d, the caused an increase of prostacyclin in carotid artery and a decrease of thromboxane A2 in blood platelets as compared to the control group. These results show that the anti-atherosclerotic action of PNS may be a result of the correction of the unbalance between prostacyclin and thromboxane A2. |
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