稳定性二氧化氯喷雾剂对家兔皮肤的刺激性实验

目的考察稳定性二氧化氯喷雾剂局部经皮给药的安全性。方法将健康家兔背部两侧对称脱毛3 cm×3 cm后,每次给予二氧化氯喷雾剂0.5 ml,对其完整皮肤和破损皮肤分别进行单次给药及多次给药的皮肤刺激性试验。结果该喷雾剂对于家兔完整皮肤和破损皮肤单次给药及多次给药后于1、24、48、72 h观察均无红肿或斑块出现。结论本试验条件下二氧化氯喷雾剂局部经皮给药无明显不良反应,表明安全性良好。为二氧化氯喷雾剂用于临床经皮给药提供可靠的试验依据和安全保障,为临床经皮给药提供一种新的二氧化氯新剂型。

A skin irritation test for transdermal administration of stabilized chloride dioxide spray in rabbits

Objective To study the safety of stabilized chlorine dioxide spray for topical transdermal delivery in rabbits. Methods Healthy rabbits were skinned at the back symmetrically on both sides to remove the hair for the area of 3 cmx3 cm. This entailed the transdermal administration of single- and multiple-dose 0.5 ml chlorine dioxide spray for subsequent skin irritation test using the intact and defected skin. Results The sprays did not exhibit red- ness or patches for the intact and defected skin at 1, 24, 48, 72 h administered with either single or multiple doses. Conclusion Chlorine dioxide spray is safe for topical transdermal delivery and lacks adverse effects, which offers re- liable rationales and a novel route for administration for clinical application.