Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats |
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Authors: | Shinomiya Kazuaki Omichi Junji Ohnishi Ryoko Ito Hideyuki Yoshida Takashi Kamei Chiaki |
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Institution: | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama 700-8530, Japan. |
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Abstract: | The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid at a dose of 500 and 200 mg/kg, respectively. On the other hand, no remarkable effects were observed with dihydrocaffeic acid even at a dose of 500 mg/kg. Caffeine caused a significant increase in sleep latency and waking time and decrease in non-rapid eye movement sleep time at a dose of 10 mg/kg. In contrast, chlorogenic acid and its metabolites had no significant effects on each sleep state. From these results, it may be concluded that chrologenic acid caused a mild arousal effect compared with that of caffeine, and the effect of chlorogenic acid may have occurred through its metabolite caffeic acid. |
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Keywords: | Sleep latency Chlorogenic acid Caffeic acid Dihydrocaffeic acid Caffeine Arousal effect |
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