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甘草酸防治肝损伤药理作用的研究进展
引用本文:张明发,沈雅琴.甘草酸防治肝损伤药理作用的研究进展[J].抗感染药学,2010,7(4):232-236.
作者姓名:张明发  沈雅琴
作者单位:上海美优制药有限公司,上海201422
摘    要:近年来国内外对甘草酸肝损伤的研究证实了甘草酸具有抗病毒、抗感染和调节机体免疫功能、、的作用(glycyrrhizic acid,GL)防治抗氧化应激抑制肝细胞凋亡和促进肝细胞再生。笔者综述了近年来甘草酸在体内外实验动物模型中,抗四氯化碳(CCl4)、D-氨基半乳糖、脂多糖,抗肝纤维化与其他类型的急性肝损伤防治等方面的药理研究进展。

关 键 词:甘草酸  肝损伤  抗病毒  肝细胞凋亡  肝细胞再生

Research Advances on Pharmacological Actions of Glycyrrhizic Acid in Prevention and Treatment of Liver Injury
ZHANG Ming-fa,SHEN Ya-qin.Research Advances on Pharmacological Actions of Glycyrrhizic Acid in Prevention and Treatment of Liver Injury[J].Anti-infection Pharmacy,2010,7(4):232-236.
Authors:ZHANG Ming-fa  SHEN Ya-qin
Institution:Shanghai Meiyou Pharmaceutical Co., Ltd, Shanghai 201422, China
Abstract:In recent years, the studies of glycyrrhizic acid in the prevention and treatment of liver injury at home and abroad have been confirmed. The glycyrrhizic acid has the effects of anti-virus, anti-inflammation, adjusting immunity, anti-oxidative stress, inhibiting liver cell apoptosis and promoting hepatocyte regeneration. The researches of prevention and treatment of glycyrrhizic acid on animal models in vivo and in vitro such as counteracting carbon tetrachloride(CCl4), D-galactosamine, lipoplysaccharide, liver fibrosis and other causes leading to acute liver injury have been reviewed.
Keywords:glycyrrhizic acid  liver injury  anti-virus  liver cell apoptosis  hepatocyte regeneration
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