羟苯磺酸钙联合海昆肾喜胶囊治疗糖尿病肾病疗效观察

目的探讨采用羟苯磺酸钙联合海昆肾喜胶囊治疗糖尿病肾病的临床疗效。方法选择2007年2月～2010年6月在笔者所在医院收治的糖尿病肾病患者80例,给予羟苯磺酸钙联合海昆肾喜胶囊治疗,就临床结果进行回顾性分析。结果联合治疗组的治疗总有效率(80.00%)高于其余两组,三者差异有统计学意义(P<0.05),3组患者治疗前Scr和BUN等指标差异无统计学意义(P>0.05)。治疗结束后,比较UAE和Scr水平,联合治疗组较单用海昆肾喜组或单用羟苯磺酸钙组下降幅度更显著(P<0.05)。联合治疗组患者出现1例腹泻;其余两组患者未发生其他并发症。结论两种药物联合运用可优势互补,延缓肾脏损伤过程,延缓肾功能下降速度。

Efficacy of 2-calcium dobesilate with Haikunshenxi capsule in the treatment of diabetic nephropathy

Objective To investigate therapeutic effect of 2-calcium dobesilate with Haikunshenxi capsule in treatment of patients with diabetic nephropathy.Methods To retrospectively analyze clinical data of 80 cases with diabetic nephropathy given 2-calcium dobesilate with Haikunshenxi in our hospital from February 2007 to June 2010.Results Thetreatment efficiency of combination therapy group (80.00%) was significantly higher than 2-calcium dobesilate group and Haikunshenxi group(P < 0.05).The decrease rate of UAE and Scr of combination therapy group was significant higher than 2-calcium dobesilate group and Haikunshenxi group(P < 0.05).Conclusion Combining 2-calcium dobesilate with Haikunshenxi in the treatment of patients with diabetic nephropathy is effective to delay the process of kidney damage and the decline rate of renal function.