| 盐酸小檗碱前体脂质体的制备及理化性质研究 |
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| 引用本文： | 杨平,林珈好,王玉蓉.盐酸小檗碱前体脂质体的制备及理化性质研究[J].中国医药科学,2012(2):32-33,41. |
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| 作者姓名： | 杨平 林珈好 王玉蓉 |
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| 作者单位： | 北京中医药大学中药学院 |
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| 摘 要： | 目的制备盐酸小檗碱前体脂质体,并对其理化性质进行考察。方法采用薄膜载体沉积法制备盐酸小檗碱前体脂质体,正交实验优选处方;透射电镜观察形态;马尔文激光粒度仪测定粒径;高效液相色谱法测定包封率。结果电镜下观察脂质体形态多为圆形或椭圆形,平均粒径为741nm,包封率为(29.93±1.32)%。结论该方法制备工艺简单,易于工业化生产。
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| 关 键 词： | 盐酸小檗碱 前体脂质体 脂质体 |
Preparation of berberine hydrochloride prolipsomes and study of its physicochemical properties |
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| YANG Ping,LIN Jiahao,WANG Yurong.Preparation of berberine hydrochloride prolipsomes and study of its physicochemical properties[J].China Medicine and Pharmacy,2012(2):32-33,41. |
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| Authors: | YANG Ping LIN Jiahao WANG Yurong |
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| Institution: | School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100102,China |
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| Abstract: | Objective To prepare berberine hydrochloride proliposomes and investigate its physicochemical properties.Methods Proliposomes were prepared by film-deposition oncarriers.Orthogonal design was used to select the optimum formulation.The shape and particle size of proliposomes were investigated by transmission electron microscope and laser scatter.The encapsulation efficiency was determined by HPLC.Results The berberine hydrochloride liposome vesicles were globular or elliptic under the electronic microscopy.The average size of the liposomes was 741nm.The encapsulation efficiency was(29.93±1.32)%.Conclusion The preparation method is simple and easily industrialized preparation. |
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| Keywords: | Berberine hydrochloride Proliposomes Liposomes |
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