盐敏感性高血压患者血清非对称二甲基精氨酸的测定及其意义

目的：探讨盐敏感性高血压患者血清非对称二甲基精氨酸（asymmetric dimethylarginine，ADMA）的测定及其意义。方法：选取100例盐敏感性高血压患者为观察组，选取100例健康体检者为对照组。比较两组血清ADMA水平、血清一氧化氮（nitric oxide， NO）水平；观察不同分级的盐敏感性高血压患者血清ADMA水平差异；采用Pearson相关分析分析血清ADMA水平与血清三酰甘油（triglyceride， TG）、血清总胆固醇（total cholesterol， TC）、血清低密度脂蛋白胆固醇（low density lipoprotein cholesterol ， LDL-C）、血清高密度脂蛋白胆固醇（high density lipoprotein cholesterol， HDL-C）、收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）的相关性。结果：观察组血清ADMA和NO水平分别为（3.8±0.8）μmol/L、（33.1±8.9）μmol/L；对照组血清ADMA和NO水平分别为（2.3±0.7）μmol/L、（54.4±10.2）μmol/L，两组比较差异具有统计学意义（P<0.05）。随着高血压分级的增高，患者血清ADMA水平明显增加，血清NO水平明显降低，I级、II级、III级患者间血清ADMA及NO水平比较差异显著（P<0.05）。 Pearson相关分析结果显示，观察组患者血清ADMA水平与SBP、DBP、LDL-C、HDL-C、TC、TG呈现正相关（P<0.05）。结论：血清ADMA水平与盐敏感性高血压的发生发展密切相关，对于病情判定和治疗具有一定价值。

The determination and significance of serum asymmetric dimethylarginine in salt-sensitive hypertension

Objective To evaluate the changes and characteristics of serum asymmetric dimethylarginine (ADMA) in salt-sensitive hypertension. Methods 100 patients with salt-sensitive hypertension were chose to observation group, 100 healthy subjects were chose to control group. The serum ADMA and nitric oxide (NO) were compared between the two groups. The serum ADMA were compared between different hypertension classification patients. Used the Pearson correlation analysis to analyze the correlation of serum ADMA , triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results The serum ADMA and NO level of observation group respectively was(3.8±0.8)μmol/L and(33.1±8.9)μmol/L, those of control group respectively was(2.3±0.7)μmol/L and(54.4±10.2)μmol/L, the difference showed statistically significant(P<0.05). With hypertension classification increased, patients serum ADMA levels increased significantly, serum NO level decreased significantly, grade I, II and III patients serum ADMA and NO level was significant difference (P<0.05). Pearson correlation analysis results showed that, the serum ADMA level of observation group had positive correlation with SBP, DBP, LDL-C, HDL-C, TC and TG(P<0.05). Conclusion Serum ADMA level is closely related to the occurrence and and development of salt-sensitive hypertension, for judgement and treatment guidance has a certain value.