| 新型口服抗癫痫药吡仑帕奈 |
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| 引用本文： | 史卫忠,徐春敏,韩容.新型口服抗癫痫药吡仑帕奈[J].药品评价,2012,0(29):33-37. |
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| 作者姓名： | 史卫忠 徐春敏 韩容 |
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| 作者单位： | 首都医科大学附属北京天坛医院药剂科 |
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| 摘 要： | 吡仑帕奈是α-氨基-3-羟基-5甲基-4-异唑丙酸受体拮抗剂,为一种具有全新作用机制的抗癫痫药,临床上用于伴有或不伴有继发性强直的12岁以上患者癫痫部分发作的辅助治疗。本文对吡仑帕奈的作用机制、药效学、药代动力学、药物相互作用、临床评价和安全性等进行综述,以期为临床合理用药提供参考。
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| 关 键 词： | 吡仑帕奈 抗癫痫药 癫痫 α-氨基-3-羟基-5甲基-4-异唑丙酸受体拮抗剂 |
Perampanel: A New Agent for Epileptic Treatment |
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| SHI Wei-zhong,XU Chun-min,HAN Rong.Perampanel: A New Agent for Epileptic Treatment[J].Drug Evaluation,2012,0(29):33-37. |
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| Authors: | SHI Wei-zhong XU Chun-min HAN Rong |
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| Institution: | Department of Pharmacy,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China |
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| Abstract: | Perampanel is a non-competitive AMPA receptor antagonist. It is a new antiepileptic drugs for adjunctive treatment of partial-onset seizures with or without secondarily generalized seizures in 12 years old and older patients with epilepsy. In order to provide reference for clinical medication, this article reviewed the mechanism, pharmacodynamics, pharmacokinetics, drug interaction, clinical evaluation, and safety ofperampanel. |
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| Keywords: | Perampanel Antiepileptic Drugs Epilepsy AMPA receptor antagonist |
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