| 降糖药物与艾塞那肽 |
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| 引用本文： | 李新刚,余克富,霍记平,赵志刚,周田彦,卢 炜.降糖药物与艾塞那肽[J].药品评价,2014(6):17-20,29. |
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| 作者姓名： | 李新刚 余克富 霍记平 赵志刚 周田彦 卢 炜 |
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| 作者单位： | [1]首都医科大学附属北京天坛医院药剂科,北京100050 [2]北京大学药学院,北京100038 |
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| 摘 要： | 目前临床上用到的降糖药物种类众多，作用机制各异。本文依作用机制将降糖药物进行了分类，并对各类药物的作用机制和特点进行了简要介绍。对全球首个上市的胰高血糖素样肽-1（Glucagon-like peptide-1，GLP-1）类似物艾塞那肽进行了重点阐述，包括氨基酸序列、作用机制、药物动力学、上市制剂和在研制剂等。
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| 关 键 词： | 降糖药物 艾塞那肽 胰高血糖素样肽-1 |
Antidiabetic Drugs and Exenatide |
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| LI Xin-gang,YU Ke-fu,HUO Ji-ping,ZHAO Zhi-gang,ZHOU Tian-yan,LU Wei.Antidiabetic Drugs and Exenatide[J].Drug Evaluation,2014(6):17-20,29. |
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| Authors: | LI Xin-gang YU Ke-fu HUO Ji-ping ZHAO Zhi-gang ZHOU Tian-yan LU Wei |
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| Institution: | 1. Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China; 2. School of Pharmaceutical Science, Peking University, Beijing 100083, China |
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| Abstract: | There are a lot of antidiabetic medications with different mechansims. The mechanism of action and characteristic of various durgs were introduced. Exenatide was the first approved drug of incretin mimetic class, which acts like the naturally occurring hormone glucagon like peptide-1 （GLP-1）. The amino acids sequence, mechanism of action, pharmacokinetic, approved-preparations, research and development of exenatide were reviewed. |
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| Keywords: | Antidiabetic Drugs Exenatide Glucagon-like Peptide-1 |
| 本文献已被 CNKI 维普 等数据库收录！ |
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