含莫西沙星方案对老年耐多药肺结核病的观察

目的 比较和评价含莫西沙星(MXFX)方案与含左氧氟沙星(LVFX)方案对老年耐多药肺结核病(MDR-PTB)的治疗效果及安全性.方法 将70例老年痰菌阳性的MDR-PTB患者随机分成试验组(T组)35例与对照组(C组)35例,T组用12 MDL2E方案;C组用12 VDL2E方案.2组患者于治疗期间前6个月均加用乌体林斯,疗程结束时可评价疗效者T组31例、C组30例.结果 治疗满2个月时痰菌阴转率T组为70.97%、C组为40.00%(P＜0.05),3个月时分别为90.32%、60.00%(P＜0.01);6个月后各期痰菌阴转率T组均大于C组,但差异无显著性(P＞0.05);满疗程时2组病灶吸收好转率分别为87.10 %、73.33%,空洞闭合率为分别20.00%、11.54%,2组对比差异无显著性(P＞0.05).副作用分别为22.86%、26.47%,差异无显著性(P＞0.05).结论 莫西沙星对老年MDR-PTB的治疗是有效且安全的.

Therapeutic effects of moxifloxacin-containing regimen and levofloxicin-containing regimen on multiple-drug resistant pulmonary tuberculois in elderly patients

objective To compare and evaluate the therapeutic efficacy and safety of moxifloxacin-containing regimen and levofloxicin-containing regimen in elderly patients with multiple-drug resistant pulmonary tuberculosis(MDR-PTB).Methods 70 elderly patients with MDR-PTB were randomly divided into two groups. 35 patients in trial group were treated by 12 MDL 2 E plan and the other 35 patients in control group were treated by 12 VDL 2 E plan. All the patients were administrated with utilins 6 months before the treatment. The results of bacteriological examination ,X ray examination and side effects of the drugs were collected and compared.At the end of treatment course the therapeutic effect could be evaluated in 31 patients of trial group and 30 patients of control group. Results At the end of two months after treatment the rates of sputum negative conversion were 70.97% in trial group and 40.00% in control group(P<0.05),and At the end of three months after treatment the rates of sputum negative conversion were 90.32% in trial group and 60.00% in control group(P<0.01). In every phases of the treatment course after 6 months,the rates of sputum negative conversion in trial group were higher than those in control group,but there were no significant differences between two groups (P>0.05). At the end of the treatment course,the rates of focus absorption improvement were 87.10% in trial group and 73.335 in control group,the cavity closure rates were 54.52% and 20.00% respectively,there were no significances between two groups(P>0.05). The incidents of side effect were 22.86% and 26.47% respectively (P>0.05),there was no significant difference between two groups(P>0.05).Conclusion Moxiflocacin is effective and safe in the treatment of MDR-PTB in elderly patients.