| 莫西沙星与左氧氟沙星对耐多药肺结核病的治疗效果 |
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| 引用本文： | 张向丛,李新霞,王淑平,张笑丹,蔡兰英,邵艳欣,白云,张俊萍,高官聚.莫西沙星与左氧氟沙星对耐多药肺结核病的治疗效果[J].河北医药,2007,29(6):557-558. |
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| 作者姓名： | 张向丛 李新霞 王淑平 张笑丹 蔡兰英 邵艳欣 白云 张俊萍 高官聚 |
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| 作者单位： | 050041,石家庄市,河北省胸科医院结核内科 |
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| 摘 要： | 目的 评价新一代氟喹诺酮类药物莫西沙星对耐多药肺结核病(MDR-PTB)的治疗作用.方法 132例 MDR-PTB患者随机分为2组:治疗组(Ⅰ组)用莫西沙星0.4 g,每日1次;对照组(Ⅱ组)用左氧氟沙星0.4 g,每日1次,疗程12月,同时辅以其他抗痨药物治疗,126例完成疗程.结果 治疗组痰菌阴转率明显高于对照组(P＜0.05),影像吸收率、副作用2组间差异无显著性(P＞0.05).结论 莫西沙星是一种安全、有效的抗MDR-PTB药物.
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| 关 键 词： | 莫西沙星 左氧氟沙星 耐多药肺结核病 临床疗效 |
| 修稿时间： | 2007-01-19 |
The therapeutic effect of moxifloxacin and levofloxacin on multiple drug resistant pulmonary tuberculosis |
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| ZHANG Xiangcong, LI Xinxia, WANG Shuping,et al..The therapeutic effect of moxifloxacin and levofloxacin on multiple drug resistant pulmonary tuberculosis[J].Hebei Medical Journal,2007,29(6):557-558. |
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| Authors: | ZHANG Xiangcong LI Xinxia WANG Shuping |
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| Institution: | Hebei Provincial Thoracic Hospital, Shijiazhuang 050041 |
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| Abstract: | Objective To evaluate the therapeutic effect ofmoxifloxacin and levofloxacin on multiple drug resistant pulmonary tuberculosis(MDR-PTB).Methods 132 patients with MDR-PTB were randomly divided into two groups.The trial group was treated with moxifloxacin 0.4g once a day,while the control group was treated with levofloxacin 0.4g once a day,with a treatment course of 12 months,at the same time the other anti-tuberculosis drugs were also used for both groups.126 patients finished the treatment course.Results The sputum negative conversion rate in trial group was significantly higher than those in control group(P<0.05).There were no significant differences in imaginga bsorption rate and side effects between two groups(P>0.05).Conclusion Moxifloxacin is an effective drug in treating MDR-PTB. |
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| Keywords: | moxifloxacin levofloxacin multiple drug resistant pulmonary tuberculosis clinical efficacy |
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