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康莱特注射液联合NP方案治疗晚期非小细胞肺癌临床疗效观察
引用本文:王振兴,张振国.康莱特注射液联合NP方案治疗晚期非小细胞肺癌临床疗效观察[J].河北医药,2007,29(1):47-48.
作者姓名:王振兴  张振国
作者单位:300450,天津市永久医院
摘    要:目的 观察康莱特注射液(KLT)联合化疗对晚期非小细胞肺癌(non-smallcelllungcancer,NSCLC)的治疗效果.方法 试验组:采用异长春花碱(NVB) 顺铂(DDP)方案化疗2个周期,同时加用康莱特注射液200 ml/d静脉滴注,21 d为1个疗程,共2个疗程.对照组单用NVB DDP.结果 两组有效率分别为59.0%(23/39)和36.6%(15/41)P<0.05,差异显著;试验组骨髓抑制发生率为23.1%(9/39),而对照为43.9%(18/41),P<0.05,差异显著;试验组消化道不良反应发生率为12.8%(5/39),对照组为24.4%(10/41),P<0.05,差异显著;试验组治疗前后KPS评分及体质量评分明显高于对照组,P<0.01,差异非常显著.结论 康莱特联合NP方案化疗可提高化疗的疗效,减轻化疗的不良反应,使患者的生存质量得到改善.

关 键 词:  非小细胞肺/药物疗法  薏苡仁/治疗应用  抗肿瘤药(中药)/治疗应用  药物疗法  联合  对比研究
修稿时间:2006-09-25

Therapeutic effect of Kanglaite injection combined with chemotherapy on advanced non-small-cell lung cancer
WANG Zhenxing,ZHANG Zhenguo.Therapeutic effect of Kanglaite injection combined with chemotherapy on advanced non-small-cell lung cancer[J].Hebei Medical Journal,2007,29(1):47-48.
Authors:WANG Zhenxing  ZHANG Zhenguo
Institution:Yongjiu Hospital, Tianjin 300450
Abstract:Objective To observe the therapeutic effect of Kanglaite injection combined with chemotherapy on advanced non-small-cell lung cancer.Methods 80 patients with non-small-cell lung cancer were randomly divided into two groups. 39 patients in trial group were treated by chemotherapy of NVP+DDP regimen combined with Kanglaite injection 200 ml/d for 42 days;41 patients in control group were treated by chemotherapy of NVB+DDP only.Results The effective rates were 59.0%(23/29) in trial group and 36.6% (15/41) in control group,there was a significant difference between two groups (P<0.05).The bone marrow suppression and digestive system side-effects in trial group were significantly lower than those in control group (P<0.05).KPS and body weight score in trial group were significantly higher than those in control group (P<0.01).Conclusions Kanglaite injection combined with chemotherapy could increase effective rate, reduce side-effects of chemotherapy and improve life quality.
Keywords:cancer  non-samll cell lung/chemotherapy  Yiyiren(kanglaite) injection/therapeutic application  anti-tumor drug (TCM)/therapeutic application  chemotherapy  combination  comparative study
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