| 乌头属植物二萜生物碱研究进展 |
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| 引用本文： | 薛姣,杨春华,刘静涵,梁敬钰,汤庆发,张思佳.乌头属植物二萜生物碱研究进展[J].海峡药学,2009,21(2):1-10. |
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| 作者姓名： | 薛姣 杨春华 刘静涵 梁敬钰 汤庆发 张思佳 |
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| 作者单位： | 1. 中国药科大学中药学院,南京,210009
2. 药物质量与安全预警教育部重点实验室(中国药科大学),南京,210009;中国药科大学分析测试中心,南京,210009 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 乌头属植物中含有的特征成份二萜生物碱具有较强的毒性和广泛生物活性，多年以来一直是药物学家寻找新药和先导化合物的一个重要来源．也是植物化学分类学家研究的热点。本文从乌头属植物中二萜生物碱的来源，结构及其特点等方面，综述了1998-2008年从乌头属植物中分得的新的二萜生物碱的研究情况。
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| 关 键 词： | 二萜生物碱 乌头属 结构特征 |
Recent advance of diterpenoid alkaloids in genus Aconitum |
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| XUE Jiao,YANG Chun-hua,LIU Jing-han,LIANG Jing-yu,TANG Qing-fa,ZHANG Si-jia.Recent advance of diterpenoid alkaloids in genus Aconitum[J].Strait Pharmaceutical Journal,2009,21(2):1-10. |
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| Authors: | XUE Jiao YANG Chun-hua LIU Jing-han LIANG Jing-yu TANG Qing-fa ZHANG Si-jia |
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| Institution: | XUE Jiao, YANG Chun-hua, LIU Jing-han, LIANG Jing-yu, TANG Qing-fa, ZHANG Si-jia( 1. School of Tra- ditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China; 2. Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China; 3.Center for Instrumental Analysis, China Pharmaceutical University, Nanjing 210009, China; 4. Key Laboratory of Research of Traditional Chinese Medicine and New Drug, Southern Medical University, Guangzhou 510515, China) |
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| Abstract: | Diterpenoid alkaloid （DA）, the characteristic components of genus Aconitum, was an important source as searching for new drugs and leading compounds for several years because of their various bioactivities and strong toxicity. The research of DA is still a hot field in the medicinal chemistry and plant taxology, New DAs seperated from genus Aconitum （from year 1998 to 2008） were summarized from the plant origins, skeleton types, and structure characters, respectively. |
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| Keywords: | Genus Aconitum Diterpenoid alkaloids Structure character |
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