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| 胶束增敏荧光法测定五聚赖氨酸-2-羰基酞菁锌 | |
| 引用本文： | 单丽,李春艳,阮冠宇,陈锦灿,黄明东.胶束增敏荧光法测定五聚赖氨酸-2-羰基酞菁锌[J].海峡药学,2011,0(8):66-68. |
| 作者姓名： | 单丽 李春艳 阮冠宇 陈锦灿 黄明东 |
| 作者单位： | 1. 福建医科大学药学院,福州,350108 2. 福建省妇幼保健院 药剂科,福州,350001 3. 中国科学院福建物质结构研究所结构化学国家重点实验室,福州,350002 |
| 摘 要： | 目的建立测定溶液及体液样本中五聚赖氨酸-2-羰基酞菁锌（ZnPc-（Lys）5）的方法。方法采用胶束增敏荧光法测定溶液及体液样本中ZnPc-（Lys）5的浓度。结果 ZnPc-（Lys）5在溶液及人体尿液和血浆样本中的线性范围均为10.0~500.0nmol.L-1;检测限分别为2.26、5.26和3.00nmol.L-1,回收率分别为98.7%~104.9%、97.1%~104.0%和93.3%~105.8%,RSD均低于5%。结论建立的胶束增敏荧光法用于溶液及体液样本中ZnPc-（Lys）5的测定准确可靠。 |
| 关 键 词： | 光敏剂 酞菁锌 十二烷基硫酸钠（SDS） 荧光光谱法 |
Determination of zinc pentalysine 2-carbonyl-phthalocyanine by micellar enhanced spectrofluorometric method |
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| SHAN Li,LI Chun-yan,RUAN Guan-yu,CHEN Jin-can,HUANG Ming-dong.Determination of zinc pentalysine 2-carbonyl-phthalocyanine by micellar enhanced spectrofluorometric method[J].Strait Pharmaceutical Journal,2011,0(8):66-68. | |
| Authors: | SHAN Li LI Chun-yan RUAN Guan-yu CHEN Jin-can HUANG Ming-dong |
| Institution: | SHAN Li1,LI Chun-yan1,RUAN Guan-yu2,CHEN Jin-can3,HUANG Ming-dong3(1.Faculty of Pharmacy,Fujian Medical University,Fuzhou,350108,China,2.Department of pharmacy,Health & care Hospital for Women and Children of Fujian province,350001,3.State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,350002,China) |
| Abstract: | OBJECTIVE To determine a novel photosensitzer zinc pentalysine 2-carbonyl-phthalocyanine(ZnPc(Lys)5) in buffer solution or body fluid.METHODS Used micellar enhanced spectrofluorometric method to determinate ZnPc(Lys)5 in buffer solution or body fluid.RESULTS Added quantum sufficit surfactant in detection system,it showed that the existence of detergent sodium dodecyl sulfate(SDS) can enhance the fluorescence intensity of ZnPc(Lys)5 greatly.The experimental conditions that influence the fluorescence intensit... |
| Keywords: | Photosensitizer Phthalocyanine zinc Sodium dodecyl sulfate(SDS) Spectrofluorometry |
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