| 车前草内生真菌w-90次级代谢产物的研究 |
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| 引用本文： | 吴萍茹,马旭闽,方金瑞.车前草内生真菌w-90次级代谢产物的研究[J].海峡药学,2005,17(6):116-119. |
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| 作者姓名： | 吴萍茹 马旭闽 方金瑞 |
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| 作者单位： | 1. 福建海洋研究所,厦门,361012
2. 厦门医药采购供应站,厦门,361004 |
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| 摘 要： | 车前草内生真菌w-90是按常规从车前草（Plantago major L．）茎部分离到的。归于拟青霉菌属（Paecilomyces sp．）。其发酵液和粗提物都有一定的抗菌活性。采用现代的分离和波谱技术。对其次级代谢产物进行了深入的研究．发现它能产生车前草的主要有效成分乌苏酸（ursolic acid）。这个事实表明：药用宿主植物的生物生理活性物质也可以由从该植物体分离得的某些内生真菌采生产。
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| 关 键 词： | 内生真菌 次级代谢产物 乌苏酸 |
| 文章编号： | 1006-3765（2005）06-0006-04 |
Studies on the Secondary Metabolites of Endophytic Fungus w-90 From the Plant Plantago Major L. |
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| WU Ping-ru,MA Xu-min,FANG Jin-rui.Studies on the Secondary Metabolites of Endophytic Fungus w-90 From the Plant Plantago Major L.[J].Strait Pharmaceutical Journal,2005,17(6):116-119. |
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| Authors: | WU Ping-ru MA Xu-min FANG Jin-rui |
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| Institution: | 1. Fujian Institute of Oceanology Xiamen 361012; 2. Xiamen Purchase and Supply Centre for Medicine Xiamen 361004,China |
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| Abstract: | The ethyl acetate extract of the Endophytic fungus w-90 from the plant Plantago major L. showed an obvious inhibition effect on bacteria and fungi. The studies on the secondary metabolites of the fungi revealed that w-90 can produce ursolic acid which was originally found in the plant Plantago major L. The fact indicates that the bioactive substances of host plant producing can produce by some Endophytic fungi isolated from host plant. |
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| Keywords: | Endophytic fungus Secondary metabolites Ursolic acid |
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