不同剂量瑞舒伐他汀对AMI患者血浆SAA、Hs-CRP、N-pro-BNP水平的影响 |
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引用本文: | 富萍,张景轩,裴晓冬,孙奡燕.不同剂量瑞舒伐他汀对AMI患者血浆SAA、Hs-CRP、N-pro-BNP水平的影响[J].中国当代医药,2013,20(8):56-57,59. |
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作者姓名: | 富萍 张景轩 裴晓冬 孙奡燕 |
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作者单位: | 沈阳医学院附属奉天医院心内科,辽宁沈阳,110024 |
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摘 要: | 目的观察不同剂量瑞舒伐他汀对急性心肌梗死(acute myocardial infarction,AMI)患者血浆血清淀粉样蛋白A(SAA)、超敏C反应蛋白(hs-CRP)、N末端B型脑钠肽前体(NT-pro-BNP)水平的影响。方法 56例急性心肌梗死患者经PCI后,接受常规治疗,随机分为两组:A组(n=28)给予瑞舒伐他汀(10mg/d),B组(n=28)强化剂量(20mg/d)治疗,两组疗程均为3个月,观察心血管事件发生情况。并设健康对照组(n=24)。结果与对照组相比,A、B两组血清hs-CRP、SAA、NT-pro-BNP水平显著升高(P〈0.05);治疗后1、2周A、B两组血清hsCRP、SAA、NT-pro-BNP水平均明显下降,差异有统计学意义(P〈0.05);且B组下降幅度更大,差异有统计学意义(P〈0.05)。随访3个月B组总心血管事件发生率明显低于A组,差异有统计学意义(P〈0.05)。结论 PCI术后给予强化瑞舒伐他汀治疗短期即可显著降低血清炎性因子,且疗效优于常规治疗剂量,有利于AMI患者的恢复。
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关 键 词: | 急性心肌梗死 瑞舒伐他汀 高敏C反应蛋白 血清淀粉样蛋白A |
Influence of different doses of rosuvastati on levels of serum high sensitivity C-reactive protein serum Amyloid A and N-terminal pro-brain natriuretic peptide in the patients with acute myocardial infarction |
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Authors: | FU Ping ZHANG Jingxuan PEI Xiaodong SUN Aoyan |
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Institution: | FU Ping ZHANG Jingxuan PEI Xiaodong SUN Aoyan( Department of Cardiology, Fengtian Hospital Affiliated to Shenyang Medical College in Liaoning Province, Shenyang 110024, China) |
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Abstract: | Objective To observe the influence of the different doses of rosuvastati on serum hs-CRP, SAA and NT- pro-BNP in the patients with acute myocardial Infarction. Methods Fifty-six cases of acute myocardial infarction patients after PCI, accepted conventional treatment, they were randomly divided into two groups: group A (n = 28) was given rosuvastati (10 mg/d), and group B (n = 28) strengthen the dose (20 mg/d) treated, two groups of treatment were for 3 months, the cardiovascular events occur was observed. And 24 healthy subjects were selected as the control group. Results Before intervention, the serum hs-CRP, SAA and NT-pro-BNP levels in group A and group B were higher than that in control group (P 〈 0.05). After treatment of one, two weeks, the serum hs-CRP, SAA and NT-pro-BNP levels in group A and group B were decreased, the difference was statistically significant (P 〈 0.05). and the decline was even greater in group B, the difference was statistically significant (P 〈 0.05). Follow-up of 3 months B group always the risk of cardiovascular events was significantly lower than the group A, the difference was statistically significant (P 〈 0.05). Conclusion PCI postoperative to strengthen rosuvastati therapy short-term can significantly reduce serum inflammatory factor, and the curative effect is better than the conventional therapeutic dose, which is beneficial to the recovery of patients with AMI. |
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Keywords: | Acute myocardial infarction Rosuvastati High sensitivity C-reactive protein Serum amyloid A |
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