影响急性缺血性脑卒中溶栓治疗预后的因素

溶栓治疗是改善急性缺血性脑卒中患者临床预后的有效治疗方法 ,但同时有再灌注损伤、症状性颅内出血、血管再闭塞等并发症,且起病至溶栓治疗时间、神经功能缺损程度、患者年龄、溶栓药物剂量、高血压、糖尿病、抗血小板药物等因素均可能增加溶栓并发症的发生及影响临床预后,在临床应用时应充分考虑影响预后的各种因素,以此指导溶栓治疗。现将临床常见影响溶栓治疗预后的因素进行综述。

Factors influencing prognosis after thrombolysis for acute ischemic stroke

Thrombolytic therapy is an effective method for improving clinical outcomes for patients with acute ischemic stroke,but at the same time it can bring some complications such as reperfusion injury,symptomatic intracranial hemorrhage,vascular re-occlusion and so on.A variety factors incuding onset to start of treatment（OTT）,degree of neurological impairment,age,thrombolytic dose,hypertension,diabetes,anti-platelet drug may increase thrombolytic complications and affect the prognosis, so in clinical practice the prognostic factors should be fully considered to guide thrombolytic therapy.The common factors influencing prognosis of thrombolytic therapy are reviewed now.