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阿替普酶静脉溶栓联合氯吡格雷、阿司匹林治疗急性心肌梗死疗效观察
引用本文:李帆,彭刚.阿替普酶静脉溶栓联合氯吡格雷、阿司匹林治疗急性心肌梗死疗效观察[J].中国当代医药,2010,17(35):20-21.
作者姓名:李帆  彭刚
作者单位:广东省梅州市蕉岭县人民医院,广东蕉岭514100
摘    要:目的:观察阿替普酶静脉溶栓联合氯吡格雷、阿司匹林治疗急性心肌梗死的疗效。方法:36例急性心肌梗死(AMI)患者给予阿替普酶静脉溶栓联合氯吡格雷、阿司匹林治疗,根据发病时间分为6h以内组及6h以上组,对比两组患者治疗前后冠脉再通率及并发症发生率。结果:36例患者静脉溶栓治疗26例,总再通率为72.2%。其中,6h以内组再通16例,再通率为80.0%,出血2例,死亡2例;6h以上至12h以内再通10例,再通率为62.5%,出血3例,死亡3例。结论:阿替普酶静脉溶栓联合氯吡格雷、阿司匹林治疗急性心肌梗死疗效好,在没有开展PCI的基层医院,是一套可行的治疗方法。

关 键 词:阿替普酶  氯吡格雷  阿司匹林  心肌梗死  静脉溶栓

Intravenous thrombolysis with alteplase combined clopidogrel and aspirin for acute myocardial infarction
Authors:LI Fan  PENG Gang
Institution:(The Pepole′s Hospital of Jiaoling County, Meizhou City, Guangdong Province, Jiaoling 514100, China)
Abstract:Objective: To investigate the thrombolytic alteplase combined clopidogrel and aspirin for acute myocardial infarction. Methods: 36 patients with acute myocardial infarction (AMI) patients given thrombolytic alteplase combined clopidogrel and aspirin therapy, according to time of onset within the group and divided into 6 hours and over 6 hours group, compared two groups of patients before and after coronary recanalization rate and complication rate. Results: 36 patients, 26 patients with intravenous thrombolytic therapy, the total recanalization rate was 72.2%. Of which, 6 hours reperfusion in 16 cases within the group, and then pass rate was 80.0%, bleeding in 2 cases and 2 deaths; 6 hours to 12 hours or less than 10 cases of reperfusion, recanalization rate was 62.5%, bleeding in 3 cases, death 3 cases. Conclusion: Intravenous thrombolysis with alteplase combined clopidogrel and aspirin for acute myocardial infarction good conduct in the absence of the primary PCI hospital, is a feasible method of treatment.
Keywords:Alteplase  Clopidogrel  Aspirin  Myocardial infarction  Intravenous thrombolysis
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