119例胃肠道间质瘤的临床诊疗分析

目的:探讨胃肠间质瘤(gastrointestinal stromal tumor,GIST)的临床特点。方法:对1995～2007年收治的119例GIST患者的临床资料进行回顾性分析。结果:免疫组织化学阳性表达率CD117为94.1%(112/119),CD34为77.3%(92/119),119例均进行外科手术,病理诊断为良性21例,恶性89例,低度恶性9例。随访114例,随访时间1～13年,良、恶性肿瘤分别为21和98例,59例转移或局部复发并死亡。结论:GIST缺乏特征性临床表现,术前确诊率低,CD117及CD34等免疫标记物配合使用可以提高胃肠道间质瘤的病理诊断准确率。预后与肿瘤大小、性质和复发转移有关(P<0.05)。

Diagnosis and treatment of gastrointestinal stromal tumors in 119 patients

Objective:To explore the clinical characteristics of gastrointestinal stromal tumors(GIST).Methods:The clinical data of 119 patients with gastrointestinal stromal tumors,who were in our hospital from 1995 to 2007,were analyzed retrospectively.Results:The surgical interventions were performed in 119 patients with GIST,among which 21 cases were benign,89 were malignant and 9 were low potential malignancies by pathologic diagnosis.114 of 119 patients were followed-up from 1 to 13 years.59 patients suffered from tumor metastasis or tumor relapse in situ,and died of GIST.Conclusion:The clinical situations of GIST have no specificity,so the rate of preoperative definite diagnosis is low.The final diagnosis of GIST depends on pathological examination.The size,characteristic and metastasis have the effect on the prognosis.