深部病原性真菌感染及耐药性分析

目的:探讨深部病原性真菌感染的特点及耐药趋势.方法:用回顾调查的方法对我院住院病人及门诊病人各类标本培养的68株病原性真菌对常用抗真菌药物药敏试验结果进行分析.结果:分离出的68株病原真菌以内科系统为主,共52株(占76.47%);检出病原性真菌最多的部位是呼吸道,占真菌标本的64.71%;真菌以白色假丝酵母菌、近平滑假丝酵母菌和类星型念球菌为主,分别占58.82%、8.82%、8.82%;药敏结果,氟胞嘧啶、两性霉素B 90%敏感,白色假丝酵母菌对氟康唑、伊曲康唑、伏立康唑的耐药率很高均在70%以上,5种常见抗真菌药物对其他病原真菌的敏感率均在90%以上.结论:加强临床病原性真菌分离株,对抗真菌药物的耐药性检测,然后根据药敏试验结果科学合理选用抗真菌药物十分重要.

Analysis of deep pathogenic fungal infection and drug resistance

Objective：To investgate the tendency of drug resistance and the characteristic of fungus infection and to provide the experiment basis for clinical selecting antifungal agents.Methods：68 strains of pathogenic fungis collected from our hospital between January 2008 to January 2009 were used to analyse the results of susceptibility test.Results：The major department of those isolated pathogenic fungis was the internal medicine,52 strains accounted for 76.4%,the major site of those isolated pathogenicity fungi was respiratory tract（64.71%） and the major type was C.albicans（58.82%）,C.parapsilosis（8.82%） and C.stellatoidea（8.82%）.Conclusion：Enhancing the detection of drug resistance of pathogenic fugus is important to select correct antifungal agent.