| 亚砷酸治疗实体恶性肿瘤的毒性反应观察 |
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| 引用本文： | 杜敏,郭超,唐兆杰,韩金娣,高文斌,王怀瑾.亚砷酸治疗实体恶性肿瘤的毒性反应观察[J].药物不良反应杂志,2004,6(5):306-308. |
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| 作者姓名： | 杜敏 郭超 唐兆杰 韩金娣 高文斌 王怀瑾 |
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| 作者单位： | 1. 大连大学附属医院,辽宁,大连,116022
2. 大连市急救中心,辽宁,大连,116021 |
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| 摘 要： | 目的:观察亚砷酸单药治疗实体恶性肿瘤的毒副反应,评价亚砷酸的安全性。方法:50例恶性肿瘤患者,应用亚砷酸静脉滴注,剂量0.1mg/(kg·d),d1-10,15d为一个周期,连续使用2个周期后评价毒性反应。结果:亚砷酸引起的Ⅰ～Ⅱ度血液(白细胞)毒性反应3例,占6%,可逆性心脏毒性反应1例,占2%,恶心,呕吐等消化道反应8例,占16%。结论:亚砷酸在实体肿瘤治疗中有一定的血液、心脏和消化道毒副反应,其反应程度轻微,临床应用安全、有效。
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| 关 键 词： | 亚砷酸 毒副反应 实体瘤 |
| 文章编号： | 1008-5734(2004)4-0306-03 |
Observation on toxic reactions caused by arsenious acid for solid carcinoma |
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| Abstract: | Objective: To observe the toxic reactions caused by arsenious acid for solid carcinoma so as to evaluate its safety in clinical practice. Methods: 50 patients with cancer received two 10-day courses of intravenous infusion of arsenious acid 0.1mg/kg/day with a 5 day interval and the resulting toxic reactions were assessed. Results: The toxic reactions were found, occurring in blood(3 cases, 6%),heart(1 case, 2%)and gastrointestinal tract (8 cases, 16%). Conclusion: Arsenious acid was proved to be safe with a mild toxic reactions during its treatment for cancer. |
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| Keywords: | arsenious acid toxic reactions solid carcinoma |
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