毒蕈中毒致急性肝衰竭3例

3例患者（男2例,女1例）,年龄分别为14、4、37岁,食用自采野生蘑菇1d后出现恶心、呕吐、腹痛、腹泻等急性胃肠道症状。经治疗上述症状无明显缓解,且出现肝及心肌损害。4d后3例患者均出现皮肤及巩膜黄染,实验室检查示ALT1101～6580U/L,AST715～1965U/L,TBil38.5～153.2μmol/L,DBil16.9～63.1μmol/L,IBil21.6～90.1μmol/L;LDH1036～2234U/L,CK-MB18～36U/L,CK30～669U/L。临床确诊为毒蕈中毒、肝衰竭。先后给予3例患者白蛋白透析、血浆置换及对症、支持治疗。住院14d后患者病情好转出院。

Acute liver failure resulting from toadstool poison in three patients

Three patients （2 men and 1 woman）,aged 14,4,37 years,took wild mushrooms picked by themselves. One day later,the 3 patients presented with nausea,vomiting,abdominal pain,diarrhea and other gastrointestinal symptoms. The above-mentioned symptoms did not relieve after treatments,and liver and cardiac muscle damage occurred. Four days later,the three patients experienced yellowish skin and sclera. Meanwhile the laboratory tests revealed ALT 1 101-6 580 U/L,AST 715-1 965 U/L,TBil 38.5-153.2 μmol/L,DBil 16.9-63.1 μmol/L,IBil 21.6-90.1 μmol/L,LDH 1 036-2 234 U/L,CK-MB 18-36 U/L,CK 30-669 U/L. Toxic mushroom poisoning and liver failure were diagnosed. The three patients were given with albumin dialysis,plasmapheresis,and symptomatic and supportive treatments. The patients＇condition improved and were discharged after 14 days of hospitalization.