莫西沙星与阿托伐他汀钙联用相关横纹肌溶解

1例80岁男性患者,因脑梗死及高脂血症口服阿托伐他汀钙20 mg,1次/d。服药20 d后出现胸痛、胸闷、无力,实验室检查示肌酸激酶(CK)由130 U/L升至741 U/L,同时出现肾功能异常和电解质紊乱。第28天,患者因肺部感染给予莫西沙星注射液0.4 g静脉滴注,之后患者CK由741 U/L升至3565 U/L,停用阿托伐他汀钙;莫西沙星改为头孢哌酮舒巴坦钠。10 d后CK逐渐下降至54 U/L,其他血生化检查均恢复正常。

Rhabdomyolysis associated with concomitant use of moxifloxacin and atorvastatin calcium

A 80-year-old man with cerebral infarction and hyperglycemia received atorvastatin calcium 20 mg once daily.The patient developed chest pain,chest distress,and asthenia 20 days after drug administration.Laboratory tests showed that creatine kinase(CK) elevated from 130 U/L to 741U/L,accompanied by abnormal renal function and electrolyte imbalances.On day 28,the patient received moxifloxacin 0.4g IV infusion for pulmonary infection.Subsequently,the patient' s CK elevated from 741U/L to 3565U/L.Atorvastatin c...