注射用脂溶性维生素（Ⅱ）致过敏性休克

1例57岁女性肺癌患者，给予注射用脂溶性维生素（Ⅱ）10ml＋0．9％氯化钠注射液250ml静脉滴注，滴速60滴／min。用药约1min后，患者出现麻木，抽搐，意识不清，全身发红，口唇发绀。立即停药，静脉推注肾上腺素0．5mg、地塞米松10mg、多巴胺40mg，予鼻导管吸氧。5min后患者神志转清，心电监护示心率127次／min，血氧饱和度0．85，血压测不出。继续给予多巴胺200mg加入0．9％氯化钠注射液50ml静脉泵入，肾上腺素2mg加入0．9％氯化钠注射液50ml静脉泵入，0．9％氯化钠注射液500ml及右旋糖酐40注射液500ml静脉滴注。2h后患者血压80／50mmHg（1mmHg=0．133kPa）。3h后血压升至130／70mmHg，血氧饱和度0．98，过敏症状消失。

Anaphylactic shock induced by fat-soluble vitamin （ Ⅱ ） for injection

A 57-year-old female with lung cancer received an IV infusion of fat-soluble vitamin （ Ⅱ ） for injection 10 ml dissolved in 250 ml of 0.9% sodium chloride injection at a rate of 60 drops/min. One minute after intravenous drip of the fat-soluble vitamin （ Ⅱ ） for injection, the patient developed a feeling of numbness, convulsion, unconsciousness, generalized redness, and lip cyanosis. The fat-soluble vitamin （ Ⅱ ） for injection was discontinued immediately, adrenaline 0.5 mg and dexamethasone 10 mg and dopamine 40 mg were given by IV bolus, and nasal cannula oxygen inhalation was given. After five minutes the patient＇ s consciousness was restored. ECG monitoring revealed a heart rate of 127 beats/min and an blood oxygen saturation was 0. 85, her blood pressure was undetectable. Dopamine 200 mg dissolved in 50 ml of 0.9% sodium chloride injection and adrenaline 2 mg dissolved in 50 ml of 0.9% sodium chloride injection were given via IV pump, and 500 ml of 0.9% sodium chloride injection and dextran 40 injection 500 ml were given by intravenous drip. Two hours later, her blood pressure was 80/50 mm Hg. Three hours later, the blood pressure increased to 130/70 mm Hg and the blood oxygen saturation increased to 0.98, her anaphylactic symptoms disappeared.