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蝮蛇抗栓酶防治实验性再狭窄
引用本文:张川,刘桂芝,季军.蝮蛇抗栓酶防治实验性再狭窄[J].中国医院药学杂志,2000,20(10):599-600.
作者姓名:张川  刘桂芝  季军
作者单位:深圳市孙逸仙心血管医院,广东,深圳,518001
摘    要:目的:研究蝮蛇抗栓酶对实验性再狭窄的影响。方法:建立再狭窄实验动物模型,肌注给药。结果:蝮蛇抗栓酶显著抑制损伤后1周时血管内膜厚度,内膜厚度/管腔直径比值,内膜面积,内膜面积/管腔面积比值。结论:早期使用蝮蛇抗栓酶是防治再狭窄的有效方法之一。

关 键 词:蝮蛇抗栓酶  内膜厚度  冠心病  冠状动脉再狭窄
文章编号:1001-5213(2000)10-0599-02
修稿时间:1999年10月28

Experimental study on ahylysantinfarctase to prevent restinosis
ZHANG Chuan,LIU Gui-Zhi,JI Jun.Experimental study on ahylysantinfarctase to prevent restinosis[J].Chinese Journal of Hospital Pharmacy,2000,20(10):599-600.
Authors:ZHANG Chuan  LIU Gui-Zhi  JI Jun
Abstract:OBJECTIVE:To investigate the effect of ahylysantinfarctase on the experimental restinosis.METHODS:A restinotic model was established.The drug was given muscularly.RESULTS:Ahylysantinfarctase could significantly inhibit the proliferative thickness and areas of the vascular intimal one week after injury and also suppress the ratio of the intimal thickness/lumen dimension and intimal area/lumen area.CONCLUSIONS:Early use of this drug to prevent and treat restionosis after intervention is one of effective methods.
Keywords:Restinosis  Ahylysantinfarctase  Intimal thickness  Intimal area
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