伊布替尼致不良反应文献分析

目的:分析伊布替尼所致不良反应(ADRs)的发生情况及临床特点,为临床安全用药提供参考。方法:检索PubMed、Web of Science、中国知网数据库、维普中文科技期刊数据库、万方数据库、中国医院知识总库关于伊布替尼不良反应的文献并进行分析。结果:伊布替尼致ADRs的个案共41例,多发生在用药30d内(13例,31.7%);伊布替尼致ADRs累及系统-器官以呼吸系统损害(13例,28.9%)、皮肤及附件损害为主(10例,22.2%)为主。结论:临床医师或药师应了解伊布替尼ADRs的发生规律和特点,尽量将ADRs的影响及危害降至最低,最大程度保障用药安全。

Literature analysis of adverse drug reactions induced by ibrutinib

OBJECTIVE To analyze the status and characteristics of adverse drug reactions(ADRs) induced by ibrutinib in order to provide references for clinical rational drug use. METHODS PubMed,Web of Science,CNKI,VIP database,Wanfang database and CHKD were searched for ADRs induced by ibrutinib,and the collected literatures were further analyzed statistically.RESULTS A total of 41 ADRs were identified and included in the analysis.ADRs of ibrutinib frequently occurred within 30 days after medication (n=13,31.7%).Ibrutinib induced ADRs were mainly respiratory system damage (n=13,28.9%) and skin and accessory lesions (n=10,22.2%).CONCLUSION Clinicians or pharmacists should understand the occurrence regularity and characteristics of ADRs,minimize the impact and harm of ADRs,and ensure the safety of medication to the greatest extent.