阿司匹林、氯吡格雷不同联合阿托伐他汀钙治疗对短暂缺血性脑缺血发作患者住院期间复发进展率的影响

目的： 分析短暂性脑缺血发作（TIA）患者中，应用阿司匹林、氯吡格雷联合他汀类药物治疗的效用。方法： 选取在其院接受治疗的116例TIA患者，收治的时间为2017年3月-2019年10月，按照不同的治疗方法将所有的患者分为3组，其中A组32例（给予阿司匹林+阿托伐他汀钙片治疗），B组20例（给予氯吡格雷+阿托伐他汀钙片），C组64例（给予氯吡格雷+阿托伐他汀钙片+阿司匹林治疗）。将3组治疗后的复发进展率、TIA发作时间、血小板计数、凝血功能、治疗效果以及不良反应发生情况进行对比。结果： 经分析，B组、C组的治疗总有效率均高于A组，差异有显著性意义（P<0.05），C组的治疗总有效率高于B组（P<0.05）；经重复测量方差分析，3组患者治疗前后不同时间的PT值比较，差异无显著性（P>0.05）；3组患者治疗前后不同时间的APTT水平比较，差异具有显著性（P<0.05）；经两两比较，C组的PT水平明显低于A组和B组（P<0.05）；经重复测量方差分析，3组患者治疗前后TIA发作时间比较，差异具有显著性（P<0.05）。治疗后，C组的复发进展率较A组和B组低（P<0.05）；3组用药后的不良反应发生率相比不具有显著性（P>0.05）。结论： 给予阿司匹林+阿托伐他汀钙片+氯吡格雷联合应用于TIA时，可以发挥协同作用，改善凝血功能，抑制血小板的聚集，机体状态改善明显，进而降低了进展复发率，且用药安全性高。

The effect of aspirin and clopidogrel combined with atorvastatin calcium treatment on the recurrence and progression rate of TIA patients during hospitalization

OBJECTIVE To analyze the efficacy of aspirin and clopidogrel combined with statins in patients with transient ischemic attack(TIA).METHODS Atotal of 116 patients with TIA who were treated in our hospital were selected from March 2017 to October 2019.All patients were divided into 3 groups according to different treatment methods,of which A group was 32 cases(aspirin was given)+ Atorvastatin calcium tablets treatment),20 cases in B groups(clopidogrel+atorvastatin calcium tablets),64 cases in C groups(clopidogrel+atorvastatin calcium tablets+Aspirin treatment).The recurrence progression rate,TIA onset time,platelet count,blood coagulation function,treatment effect and occurrence of adverse reactions after the three groups were compared.RESULTS After analysis,the total effective rate of treatment in the B group was higher than that in the A group(P<0.06),C group was higher than that of the A group and the B groups(P<0.05);After repeated measures analysis of variance,the three groups were different before and after treatment there was no statistically significant difference in the PT value of time(P<0.05);APTT at different times before and after treatment in the three groups comparison of levels,the difference is statistically significant(P<0.05);After pairwise comparison,the PT levels of the C group are significantly lower In B groups and A group(P<0.05);After repeated measures analysis of variance,the comparison of the onset time of TIA between the three groups of patients before and after treatment,the difference was statistically significant(P<0.05).After treatment,the recurrence progression rate of the C group was lower than that of the B group and A group(P<0.05);The incidence of adverse reactions after the three groups was not different(P>0.05).CONCLUSION The combination of aspirin+atorvastatin calcium tablets+clopidogrel in TIA can exert a synergistic effect,improve coagulation function,inhibit platelet aggregation,and improve the body condition significantly,thereby reducing the progression and recurrence rate,and the medication is safe High sex.