帕金森病合并癫痫的治疗

帕金森病和癫痫均为常见的神经系统慢性疾病,但帕金森病合并癫痫在临床上较为少见,部分研究显示帕金森病患者癫痫发作风险增加。脑深部电极刺激术为帕金森病外科治疗的主要选择,但其并发症包括癫痫发作,与较高的发病率和死亡率有关。此外,帕金森合并癫痫患者认知障碍风险增加,一线治疗药物胆碱酯酶抑制剂存在着诱发或加重癫痫发作的可能,而唑尼沙胺是目前唯一可用于帕金森病治疗的抗癫痫药物。本文就帕金森病合并癫痫患者治疗过程中的关键问题进行阐述,以期为临床治疗提供参考。

The treatment of Parkinson's disease coexisted with epilepsy

Parkinson's disease and epilepsy are common chronic neurological diseases, but Parkinson's disease coexisted with epilepsy is relatively rare in clinical practice. Several studies have shown that patients with Parkinson's disease have an increased risk of epileptic seizures. Deep brain electrical stimulation is a major option for the surgical treatment of Parkinson's disease, but its complications included epileptic seizures, which are associated with higher morbidity and mortality. In addition, the study revealed that there is an increased risk of cognitive impairment in patients who suffered from Parkinson's disease and epilepsy. Given that first-line treatment of cholinesterase inhibitors may induce or aggravate seizures, zonisamide is the sole antiepileptic drug available for the treatment of Parkinson's disease, currently. This article expounds the key problems related to the treatment of Parkinson's disease patients with epilepsy so as to provide reference for clinical treatment.