| 中日金星蕨的抗炎作用及其机制 |
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| 引用本文： | 宋丹,付伟,阮金兰.中日金星蕨的抗炎作用及其机制[J].中国医院药学杂志,2011(8). |
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| 作者姓名： | 宋丹 付伟 阮金兰 |
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| 作者单位： | 武汉市普爱医院;华中科技大学同济药学院; |
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| 摘 要： | 目的:研究中日金星蕨抗炎作用及其作用机制。方法:观察中日金星蕨对角叉菜胶所致大鼠足肿胀炎症组织中前列腺素E2(PGE2)、丙二醛(MDA)、一氧化氮(NO)及一氧化氮合酶(T-NOS)含量的影响。结果:中日金星蕨乙醇提取物(400,800,1600mg.kg-1)对角叉菜胶所致大鼠足肿胀有显著的抑制作用,并呈剂量依赖关系。与模型组比较,该提取物低、中、高剂量组能抑制大鼠足肿胀组织中PGE2的含量,抑制率分别为34.2%,57.9%和71.1%;减少大鼠足肿胀组织中MDA的含量,抑制率分别为14.8%,36.6%和65.5%;减少大鼠足肿胀组织中NO的含量,抑制率分别为21.7%,32.5%和40.3%;降低大鼠足肿胀组织中T-NOS的活性,抑制率分别为25.0%,56.7%和69.0%。结论:中日金星蕨抑制角叉菜胶致大鼠足肿胀可能是通过抑制脂质过氧化物的形成和影响炎症介质的释放而实现的。
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| 关 键 词： | 中日金星蕨 抗炎作用 角叉菜胶 炎症介质 |
Study on the anti-inflammatory effect and mechanism of the extract from Parathelypteris nipponica(Franch. et Sav.) Ching |
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| SONG Dan,FU Wei,RUAN Jin-lan.Study on the anti-inflammatory effect and mechanism of the extract from Parathelypteris nipponica(Franch. et Sav.) Ching[J].Chinese Journal of Hospital Pharmacy,2011(8). |
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| Authors: | SONG Dan FU Wei RUAN Jin-lan |
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| Institution: | SONG Dan1,FU Wei2,RUAN Jin-lan2 (1.Wuhan Puai Hospital,Hubei Wuhan 430033,China,2.College of Pharmacy,Tongji Medical Center,University of Science and Technology,Hubei Wuhan 430030,China) |
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| Abstract: | OBJECTIVE To study the anti-inflammatory effect of the ethanolic extract from Parathelypteris nipponica(Franch.et Sav.) Ching(TEPN) and its mechanism of action.METHODS The effect of TEPN on the production of prostaglandin E2(PGE2),generation of malondialdehyde(MDA),nitric oxide(NO) and total nitric oxide synthase(T-NOS) were observed in the carrageenin-induced inflammatory tissue of rats pau.RESULTS TEPN(400,800,1600 mg/kg) reduced carrageenin-induced rat paw oedema in dose-dependent manner,achieving high d... |
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| Keywords: | Parathelypteris nipponica(Franch et Sav ) Ching anti-inflammatory carrageenin inflammatory mediators |
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