基于加权TOPSIS法的硫酸多黏菌素B药物利用评价

目的： 基于加权优劣解距离法（TOPSIS）对注射用硫酸多黏菌素B的临床使用进行评价，为其合理应用提供参考依据。方法： 以注射用硫酸多黏菌素B的药品说明书为基础，参照多黏菌素B相关专家共识等，建立基于加权TOPSIS法的硫酸多黏菌素B药物利用评价细则，以此为依据，对中山市人民医院2018年1月—2020年12月期间77例住院患者硫酸多黏菌素B的使用情况进行评价。结果： 评价的77份病历中，与最优方案相对接近程度（C_i）介于80%~90%的31例（占比40.2%），介于70%~80%的27例（占比35.1%），介于60%~70%的17例（占比22.1%），C_i在50%~60%的2例（占比2.60%）。结论： 通过基于加权TOPSIS法的硫酸多黏菌素B药物利用评价，可以发现多黏菌素B使用存在的问题，药学部门后续可进行针对性药学干预，促进其合理使用。

Drug use evaluation of polymyxin B sulphas for injection based on weighted TOPSIS method

OBJECTIVE To establish the detailed rules for the utilization evaluation of polymyxin B sulphas for injection, and evaluate the use of polymyxin B sulphas by using the weighted technique for order preference by similarity to ideal solution(TOPSIS) to provide reference for its clinical rational application.METHODS Based on polymyxin B sulphas for injection instructions, referring to the consensus of experts on polymyxin B, and according to the weighted TOPSIS method, the evaluation rules of polymyxin B sulphas for injection were established. Based on this, the use of polymyxin B sulphas for injection in 77 inpatients of a hospital from January 2018 to December 2020 was evaluated.RESULTS Among the 77 cases, relative proximity to the optimal scheme of 31 cases(40.2%) was between 80%-90%, that of 27 cases(35.1%) was between 70%-80%, that of 17 cases(22.1%) was between 60%-70%, and that of 2 cases(2.60%) was between 50%-60%.CONCLUSION Through the weighted TOPSIS method for polymyxin B sulphas utilization evaluation, the problems in the use of polymyxini B sulphas can be found, and pharmacy department can carry out targeted pharmaceutical interventions to promote its rational use.