| 心痛定片剂与滴丸的人体生物利用度及药代动力学的研究 |
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| 引用本文： | 徐凯建 张慧君. 心痛定片剂与滴丸的人体生物利用度及药代动力学的研究[J]. 中国医院药学杂志, 1994, 14(3): 106-108 |
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| 作者姓名： | 徐凯建 张慧君 |
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| 作者单位： | 哈尔滨医科大学临床药学药物研究所 |
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| 摘 要： | 本文采用高压液相色谱法测定心痛定片剂与滴丸的人体血药浓度。流动相：甲醇（色谱纯）─磷酸盐缓冲液（６０：４０），紫外检测波长２３５ｎｍ，以片剂为标准制剂，滴丸的相对生物利用度为１２２．０％。对片剂与滴丸的ＡＵＣ、Ｃｍａｘ、Ｔｍａｘ作ｔ检验，结果二者之间Ｃｍａｘ、Ｔｍａｘ有显著性差异（Ｐ＜０．０５），ＡＵＣ无显著差异（Ｐ＞０．０５），结果表明滴丸较片剂优良。
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| 关 键 词： | 心痛定，高压液相色谱法，生物利用度，药代动力学 |
Study on the bioavailability and pharmacokinetics of nifedipine tablets and pills in healthy volunteers |
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| Xu Kai-jian,Zhang Hui-jun,Lu Yi-cheng,et al. Study on the bioavailability and pharmacokinetics of nifedipine tablets and pills in healthy volunteers[J]. Chinese Journal of Hospital Pharmacy, 1994, 14(3): 106-108 |
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| Authors: | Xu Kai-jian Zhang Hui-jun Lu Yi-cheng et al |
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| Abstract: | he plasma concentrations of Nifedipine tablets and pills in healthy volunteers were determined by HPLC respectively.The mobile phase was methanol-phosphate buffer(60:40 ,UV detection wavelength was 235 nm. The relative bioavailabitityof pills was 122.0%as compared with the tablets. Through t-test,significant difference of Cmax ,Tmax between tablets andpills was found( p<0. 05)and no significant difference of AUC was found( p<0.05).The results showed that the pills ofNifedipin was better than tablets. |
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| Keywords: | Nifedipine HPLC bioavailability pharmacokinetics |
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