| 中心复合设计法优化氧化苦参碱生物黏附缓释片处方 |
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| 引用本文： | 赵存婕,尹莉芳,周建平,马伟.中心复合设计法优化氧化苦参碱生物黏附缓释片处方[J].中国医院药学杂志,2007,27(8):1025-1028. |
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| 作者姓名： | 赵存婕 尹莉芳 周建平 马伟 |
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| 作者单位： | 中国药科大学药学院,江苏,南京,210009 |
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| 基金项目： | 国家“863”计划创新药物和中药现代化重大专项(编号:2004AA2Z3080) |
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| 摘 要： | 目的:选用羟丙甲纤维素和卡波姆为生物黏附材料和骨架材料制备氧化苦参碱生物黏附缓释片。方法:采用中心复合设计法优化处方。以体外释放综合评分值和黏附力为考察指标对羟丙甲纤维素的用量和卡波姆用量2个自变量进行多元线性回归和二项式拟合,并进行预测分析。结果:2个影响因素和2个评价指标之间存在定量关系,优化处方各指标的预测值和目标值接近。结论:经中心复合设计优化的氧化苦参碱生物黏附缓释片处方可行。
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| 关 键 词： | 氧化苦参碱 生物黏附缓释片 释放度 中心复合设计 |
| 文章编号： | 1001-5213（2007）08-1025-04 |
| 修稿时间： | 2006-10-08 |
Optimazation of the bio-adhesive oxymatrine sustained-release tablets by central composite design |
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| ZHAO Cun-jie,YIN Li-fang,ZHOU Jian-ping,MA Wei.Optimazation of the bio-adhesive oxymatrine sustained-release tablets by central composite design[J].Chinese Journal of Hospital Pharmacy,2007,27(8):1025-1028. |
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| Authors: | ZHAO Cun-jie YIN Li-fang ZHOU Jian-ping MA Wei |
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| Institution: | Pharmacy college of China Pharmaceutical University, Jiangsu Nanjing 210009,China |
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| Abstract: | OBJECTIVE To prepare bio-adhesive sustained-release tablets of oxymatrine using HPMCK 15M and cabopol 934p as the bio-adhesive and binding materials.METHODS The optimal formulation was obtained by central composite design.The effect of formulation factors(amount of cabopol,amount of HPMCK15M)on the response was systemically investigated.The response was the grading values of synthesizing of release in vitro and the adhesion.The linear model and quadratic model was used to analyze experimental data.RESULTS The quantitative relationships between the two factors and two evaluation indexes were obtained.The predicted and observed values of the optimum formulation was close.CONCLUSION Central composite design was successfully used to optimize the bio-adhesive sustained-release tablets of oxymatrine. |
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| Keywords: | oxymatrine bio-adhesive sustained-release tablets dissolution central composite design |
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