盐酸曲马多注射液与甲磺酸罗哌卡因注射液配伍的稳定性考察

目的考察盐酸曲马多注射液与甲磺酸罗哌卡因注射液在0.9%氯化钠注射液中的配伍稳定性。方法采用高效液相色谱法（HPLC）测定配伍液中盐酸曲马多与甲磺酸罗哌卡因在72 h内的含量变化,并观察和检测配伍液的外观、不溶性微粒及pH值变化。结果盐酸曲马多注射液与甲磺酸罗哌卡因注射液在0.9%氯化钠注射液中配伍后,在室温条件下放置72 h内的配伍液含量、外观、不溶性微粒与pH值等几项指标均未见明显变化。结论在室温条件下,盐酸曲马多注射液与甲磺酸罗哌卡因注射液在0.9%氯化钠注射液中72 h内均保持稳定。

Compatibility of tramadol hydrochloride injection with ropivacaine mesylate injection

Objective To study the stability of tramadol hydrochloride injection with ropivacaine mesylate injection in 0.9% sodium chloride injection.Methods By HPLC,we determined the content of tramadol hydrochloride and ropivacaine mesylate in the mixture solution at 72 h,and the appearance of the mixture solution was observed and its pH value and particles were determined.Results There were no significantly changes in the appearance,pH values,particles and contents of tramadol hydrochloride and ropivacaine mesylate in the mixture solution within 72 h at room temperature.Conclusion The mixture of tramadol hydrochloride with ropivacaine mesylate 0.9% sodium chloride injection is stable within 72 h under room temperature.