| 黄荆子三萜类化学成分研究 |
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| 引用本文： | 王雅静,何熙,曾光尧,谭健兵,李鑫,周应军. 黄荆子三萜类化学成分研究[J]. 中南药学, 2012, 10(6): 409-412 |
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| 作者姓名： | 王雅静 何熙 曾光尧 谭健兵 李鑫 周应军 |
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| 作者单位： | 中南大学药学院,长沙,410013 |
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| 基金项目： | 国家科技重大专项-重大新药创制(编号:2009ZX09102-109) |
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| 摘 要： | 目的 研究马鞭草科牡荆属植物黄荆果实的三萜类化学成分.方法 采用硅胶柱层析、ODS柱层析、Sephadex LH-20柱层析等色谱法分离纯化黄荆子三萜类化学成分,并根据理化性质和波谱数据对化合物结构进行鉴定.结果 分离得到了7个化合物,分别是2α,3α,19α-三羟基乌苏-12-烯-28-酸(1)、2α,3β-二羟基齐墩果-12-烯-28-酸(2)、2α,3β,19α-三羟基乌苏-12-烯-28-酸(3)、2α,3ββ,19α,23-四羟基齐墩果-12-烯-28-酸(4)、2α,3β,23-三羟基齐墩果-12-烯-28-酸(5)、2α,3α,24-齐墩果三羟基-12-烯-28-酸(6)、乌苏酸(7).结论 化合物1、3、4、5、6为首次从该属植物中分离得到.
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| 关 键 词： | 黄荆子 三萜 化学成分 |
Constituents of triterpenes in the seeds of Vitex negundo L. |
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| WANG Ya-jing , HE Xi , ZENG Guang-yao , TAN Jian-bing , LI Xin , ZHOU Ying-jun. Constituents of triterpenes in the seeds of Vitex negundo L.[J]. Central South Pharmacy, 2012, 10(6): 409-412 |
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| Authors: | WANG Ya-jing HE Xi ZENG Guang-yao TAN Jian-bing LI Xin ZHOU Ying-jun |
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| Affiliation: | (School of Pharmaceutical Sciences,Central South University,Changsha 410013) |
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| Abstract: | Objective To determine the constituents of triterpenes in the seeds of Vitex negundo L.Methods The triterpenes constituents were isolated and purified by Silica gel,ODS and Sephadex LH-20 column chromatography,and their structures were elucidated by chemical and spectroscopic methods.Results Seven compounds were identified:2α,3α,19α-trihydroxyoic-12-en-28-acid(1),2α,3β-dihydroxy bearing-12-en-28-acid(2),2α,3β,19α-trihydroxyoic-12-en-28-acid(3),2α,3β,19α,23-tetrahydroxybearing-12-en-28-acid(4),2α,3β,23-trihydroxybearing-12-en-28-acid(5),2α,3α,24-oleanolic trihydroxy-12-en-28-acid(6) and ursolic acid(7).Conclusion Compounds 1,3,4,5 and 6 have been obtained from this genus for the first time. |
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| Keywords: | Vitex negundo L. triterpenes chemical constituent |
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