| 诺氟沙星-磺丁基醚-β-环糊精包合物的研究 |
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| 引用本文： | 李文妍,谷福根,孟根达来,王毅,张爱武,郭智,吴春芝.诺氟沙星-磺丁基醚-β-环糊精包合物的研究[J].中南药学,2011,9(2):81-84. |
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| 作者姓名： | 李文妍 谷福根 孟根达来 王毅 张爱武 郭智 吴春芝 |
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| 作者单位： | 1. 内蒙古医学院药学院,呼和浩特,010010
2. 内蒙古医学院附属医院药剂部,呼和浩特,010059 |
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| 基金项目： | 内蒙古自然科学基金资助课题 |
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| 摘 要： | 目的制备诺氟沙星(NFX)与磺丁基醚-β-环糊精(SBE-β-CD)包合物,并考察其溶解度、溶出度以及化学稳定性的变化。方法以相溶解度法研究SBE-β-CD对NFX的包合作用;采用冷冻干燥法制备NFX-SBE-β-CD包合物,以红外光谱法(IR)与X-射线衍射法对其进行物相鉴定,同时考察NFX经SBE-β-CD包合后,其溶解度、溶出度以及化学稳定性的变化。结果 NFX与SBE-β-CD在溶液与固体状态下均可形成包合物;NFX经SBE-β-CD包合后,其溶解度、溶出速率显著增加,化学稳定性有所提高。结论 SBE-β-CD可明显增加NFX的溶解度、溶出速度,并改善其化学稳定性。
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| 关 键 词： | 诺氟沙星 磺丁基醚-β-环糊精 溶解度 溶出度 化学稳定性 |
Preparation and characterization of norfloxacin-sulfobutylether-β-cyclodextrin complex |
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| LI Wen-yan,GU Fu-gen,Meng-Gen-Da-lai,WANG Yi,ZHANG Ai-wu,GUO Zhi,WU Chun-zhi.Preparation and characterization of norfloxacin-sulfobutylether-β-cyclodextrin complex[J].Central South Pharmacy,2011,9(2):81-84. |
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| Authors: | LI Wen-yan GU Fu-gen Meng-Gen-Da-lai WANG Yi ZHANG Ai-wu GUO Zhi WU Chun-zhi |
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| Institution: | LI Wen-yan1,GU Fu-gen2,Meng-Gen-Da-lai2,WANG Yi2,ZHANG Ai-wu2,GUO Zhi2,WU Chun-zhi2(1.School of Pharmacy,Medical College of Inner Mongolia,Hohhot 010010,2.Department of Pharmacy,Affiliated Hospital of Medical College of Inner Mongolia,Hohhot 010059) |
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| Abstract: | Objective To study and prepare NFX-SBE-β-CD solid complex and further investigate its properties such as solubility,dissolution rate and chemical stability.Methods The complexation and concurrent solubilizing effect of SBE-β-CD on NFX were studied by phase solubility method.NFX-SBE-β-CD complex was prepared by lyophilization method and characterized by infrared spectroscopy（IR） and X-ray diffraction.The solubility,dissolution rate and chemical stability of the prepared complex were also examined.Results The stable complex of NFX with SBE-β-CD could be formed either in solution or in solid form.The solubility,dissolution rate and chemical stability of NFX were obviously improved by SBE-β-CD as a result of complexation.Conclusion SBE-β-CD significantly improves the solubility,dissolution rate and chemical stability of NFX. |
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| Keywords: | norfloxacin SBE-β-CD solubility dissolution rate chemical stability |
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